Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping

Non-small cell lung cancers (NSCLC), in particular adenocarcinoma, are often mixed with normal cells. Therefore, low sensitivity of direct sequencing used for K-Ras mutation analysis could be inadequate in some cases. Our study focused on the possibility to increase the detection of K-Ras mutations...

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Detalles Bibliográficos
Autores principales: Beau-Faller, M, Legrain, M, Voegeli, A-C, Guérin, E, Lavaux, T, Ruppert, A-M, Neuville, A, Massard, G, Wihlm, J-M, Quoix, E, Oudet, P, Gaub, M P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661785/
https://www.ncbi.nlm.nih.gov/pubmed/19293811
http://dx.doi.org/10.1038/sj.bjc.6604925

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