Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients

Among 242 Japanese pancreatic cancer patients, three patients (1.2%) encountered life-threatening toxicities, including myelosuppression, after gemcitabine-based chemotherapies. Two of them carried homozygous CDA*3 (CDA208G>A [Ala70Thr]), and showed extremely low plasma cytidine deaminase activit...

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Autores principales: Ueno, H, Kaniwa, N, Okusaka, T, Ikeda, M, Morizane, C, Kondo, S, Sugiyama, E, Kim, S R, Hasegawa, R, Saito, Y, Yoshida, T, Saijo, N, Sawada, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661788/
https://www.ncbi.nlm.nih.gov/pubmed/19293806
http://dx.doi.org/10.1038/sj.bjc.6604971
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author Ueno, H
Kaniwa, N
Okusaka, T
Ikeda, M
Morizane, C
Kondo, S
Sugiyama, E
Kim, S R
Hasegawa, R
Saito, Y
Yoshida, T
Saijo, N
Sawada, J
author_facet Ueno, H
Kaniwa, N
Okusaka, T
Ikeda, M
Morizane, C
Kondo, S
Sugiyama, E
Kim, S R
Hasegawa, R
Saito, Y
Yoshida, T
Saijo, N
Sawada, J
author_sort Ueno, H
collection PubMed
description Among 242 Japanese pancreatic cancer patients, three patients (1.2%) encountered life-threatening toxicities, including myelosuppression, after gemcitabine-based chemotherapies. Two of them carried homozygous CDA*3 (CDA208G>A [Ala70Thr]), and showed extremely low plasma cytidine deaminase activity and gemcitabine clearance. Our results suggest that homozygous *3 is a major factor causing gemcitabine-mediated severe adverse reactions among the Japanese population.
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spelling pubmed-26617882010-03-24 Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients Ueno, H Kaniwa, N Okusaka, T Ikeda, M Morizane, C Kondo, S Sugiyama, E Kim, S R Hasegawa, R Saito, Y Yoshida, T Saijo, N Sawada, J Br J Cancer Clinical Study Among 242 Japanese pancreatic cancer patients, three patients (1.2%) encountered life-threatening toxicities, including myelosuppression, after gemcitabine-based chemotherapies. Two of them carried homozygous CDA*3 (CDA208G>A [Ala70Thr]), and showed extremely low plasma cytidine deaminase activity and gemcitabine clearance. Our results suggest that homozygous *3 is a major factor causing gemcitabine-mediated severe adverse reactions among the Japanese population. Nature Publishing Group 2009-03-24 2009-03-17 /pmc/articles/PMC2661788/ /pubmed/19293806 http://dx.doi.org/10.1038/sj.bjc.6604971 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical Study
Ueno, H
Kaniwa, N
Okusaka, T
Ikeda, M
Morizane, C
Kondo, S
Sugiyama, E
Kim, S R
Hasegawa, R
Saito, Y
Yoshida, T
Saijo, N
Sawada, J
Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients
title Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients
title_full Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients
title_fullStr Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients
title_full_unstemmed Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients
title_short Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients
title_sort homozygous cda*3 is a major cause of life-threatening toxicities in gemcitabine-treated japanese cancer patients
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661788/
https://www.ncbi.nlm.nih.gov/pubmed/19293806
http://dx.doi.org/10.1038/sj.bjc.6604971
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