Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients

Among 242 Japanese pancreatic cancer patients, three patients (1.2%) encountered life-threatening toxicities, including myelosuppression, after gemcitabine-based chemotherapies. Two of them carried homozygous CDA*3 (CDA208G>A [Ala70Thr]), and showed extremely low plasma cytidine deaminase activit...

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Detalles Bibliográficos
Autores principales: Ueno, H, Kaniwa, N, Okusaka, T, Ikeda, M, Morizane, C, Kondo, S, Sugiyama, E, Kim, S R, Hasegawa, R, Saito, Y, Yoshida, T, Saijo, N, Sawada, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661788/
https://www.ncbi.nlm.nih.gov/pubmed/19293806
http://dx.doi.org/10.1038/sj.bjc.6604971

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