A Fluorous-Tagged “Safety Catch” Linker for Preparing Heterocycles by Ring-Closing Metathesis

[Image: see text] A fluorous-tagged “safety catch” linker is described for the synthesis of heterocycles with use of ring-closing metathesis. The linker facilitiates the purification of metathesis substrates, the removal of the catalyst, the functionalization of the products, and the release of only...

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Detalles Bibliográficos
Autores principales: O’Leary-Steele, Catherine, Cordier, Christopher, Hayes, Jerome, Warriner, Stuart, Nelson, Adam
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662370/
https://www.ncbi.nlm.nih.gov/pubmed/19173645
http://dx.doi.org/10.1021/ol802848j
Descripción
Sumario:[Image: see text] A fluorous-tagged “safety catch” linker is described for the synthesis of heterocycles with use of ring-closing metathesis. The linker facilitiates the purification of metathesis substrates, the removal of the catalyst, the functionalization of the products, and the release of only metathesis products. The synthesis of a range of heterocycles is described.

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