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Peroxisome Proliferator-Activated Receptors in HCV-Related Infection
The topic of peroxisome proliferator-activated receptors has been developed in the field of hepatology allowing envisaging therapeutic strategies for the most frequent chronic liver diseases such as chronic infection with hepatitis C virus (HCV). PPARs contribute to wide physiological processes with...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662434/ https://www.ncbi.nlm.nih.gov/pubmed/19343188 http://dx.doi.org/10.1155/2009/357204 |
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author | Dharancy, Sébastien Lemoine, Maud Mathurin, Philippe Serfaty, Lawrence Dubuquoy, Laurent |
author_facet | Dharancy, Sébastien Lemoine, Maud Mathurin, Philippe Serfaty, Lawrence Dubuquoy, Laurent |
author_sort | Dharancy, Sébastien |
collection | PubMed |
description | The topic of peroxisome proliferator-activated receptors has been developed in the field of hepatology allowing envisaging therapeutic strategies for the most frequent chronic liver diseases such as chronic infection with hepatitis C virus (HCV). PPARs contribute to wide physiological processes within the liver such as lipid/glucid metabolisms, inflammatory response, cell differentiation, and cell cycle. In vitro experiments and animal studies showed that PPARα discloses anti-inflammatory property, and PPARγ discloses anti-inflammatory, antifibrogenic, and antiproliferative properties in the liver. Experimental and human studies showed impaired PPARs expression and function during HCV infection. The available nonhepatotoxic agonists of PPARs may constitute a progress in the therapeutic management of patients chronically infected with HCV. |
format | Text |
id | pubmed-2662434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-26624342009-04-02 Peroxisome Proliferator-Activated Receptors in HCV-Related Infection Dharancy, Sébastien Lemoine, Maud Mathurin, Philippe Serfaty, Lawrence Dubuquoy, Laurent PPAR Res Review Article The topic of peroxisome proliferator-activated receptors has been developed in the field of hepatology allowing envisaging therapeutic strategies for the most frequent chronic liver diseases such as chronic infection with hepatitis C virus (HCV). PPARs contribute to wide physiological processes within the liver such as lipid/glucid metabolisms, inflammatory response, cell differentiation, and cell cycle. In vitro experiments and animal studies showed that PPARα discloses anti-inflammatory property, and PPARγ discloses anti-inflammatory, antifibrogenic, and antiproliferative properties in the liver. Experimental and human studies showed impaired PPARs expression and function during HCV infection. The available nonhepatotoxic agonists of PPARs may constitute a progress in the therapeutic management of patients chronically infected with HCV. Hindawi Publishing Corporation 2009 2009-03-30 /pmc/articles/PMC2662434/ /pubmed/19343188 http://dx.doi.org/10.1155/2009/357204 Text en Copyright © 2009 Sébastien Dharancy et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Dharancy, Sébastien Lemoine, Maud Mathurin, Philippe Serfaty, Lawrence Dubuquoy, Laurent Peroxisome Proliferator-Activated Receptors in HCV-Related Infection |
title | Peroxisome Proliferator-Activated Receptors in HCV-Related Infection |
title_full | Peroxisome Proliferator-Activated Receptors in HCV-Related Infection |
title_fullStr | Peroxisome Proliferator-Activated Receptors in HCV-Related Infection |
title_full_unstemmed | Peroxisome Proliferator-Activated Receptors in HCV-Related Infection |
title_short | Peroxisome Proliferator-Activated Receptors in HCV-Related Infection |
title_sort | peroxisome proliferator-activated receptors in hcv-related infection |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662434/ https://www.ncbi.nlm.nih.gov/pubmed/19343188 http://dx.doi.org/10.1155/2009/357204 |
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