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Peroxisome Proliferator-Activated Receptors in HCV-Related Infection

The topic of peroxisome proliferator-activated receptors has been developed in the field of hepatology allowing envisaging therapeutic strategies for the most frequent chronic liver diseases such as chronic infection with hepatitis C virus (HCV). PPARs contribute to wide physiological processes with...

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Detalles Bibliográficos
Autores principales: Dharancy, Sébastien, Lemoine, Maud, Mathurin, Philippe, Serfaty, Lawrence, Dubuquoy, Laurent
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662434/
https://www.ncbi.nlm.nih.gov/pubmed/19343188
http://dx.doi.org/10.1155/2009/357204
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author Dharancy, Sébastien
Lemoine, Maud
Mathurin, Philippe
Serfaty, Lawrence
Dubuquoy, Laurent
author_facet Dharancy, Sébastien
Lemoine, Maud
Mathurin, Philippe
Serfaty, Lawrence
Dubuquoy, Laurent
author_sort Dharancy, Sébastien
collection PubMed
description The topic of peroxisome proliferator-activated receptors has been developed in the field of hepatology allowing envisaging therapeutic strategies for the most frequent chronic liver diseases such as chronic infection with hepatitis C virus (HCV). PPARs contribute to wide physiological processes within the liver such as lipid/glucid metabolisms, inflammatory response, cell differentiation, and cell cycle. In vitro experiments and animal studies showed that PPARα discloses anti-inflammatory property, and PPARγ discloses anti-inflammatory, antifibrogenic, and antiproliferative properties in the liver. Experimental and human studies showed impaired PPARs expression and function during HCV infection. The available nonhepatotoxic agonists of PPARs may constitute a progress in the therapeutic management of patients chronically infected with HCV.
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spelling pubmed-26624342009-04-02 Peroxisome Proliferator-Activated Receptors in HCV-Related Infection Dharancy, Sébastien Lemoine, Maud Mathurin, Philippe Serfaty, Lawrence Dubuquoy, Laurent PPAR Res Review Article The topic of peroxisome proliferator-activated receptors has been developed in the field of hepatology allowing envisaging therapeutic strategies for the most frequent chronic liver diseases such as chronic infection with hepatitis C virus (HCV). PPARs contribute to wide physiological processes within the liver such as lipid/glucid metabolisms, inflammatory response, cell differentiation, and cell cycle. In vitro experiments and animal studies showed that PPARα discloses anti-inflammatory property, and PPARγ discloses anti-inflammatory, antifibrogenic, and antiproliferative properties in the liver. Experimental and human studies showed impaired PPARs expression and function during HCV infection. The available nonhepatotoxic agonists of PPARs may constitute a progress in the therapeutic management of patients chronically infected with HCV. Hindawi Publishing Corporation 2009 2009-03-30 /pmc/articles/PMC2662434/ /pubmed/19343188 http://dx.doi.org/10.1155/2009/357204 Text en Copyright © 2009 Sébastien Dharancy et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dharancy, Sébastien
Lemoine, Maud
Mathurin, Philippe
Serfaty, Lawrence
Dubuquoy, Laurent
Peroxisome Proliferator-Activated Receptors in HCV-Related Infection
title Peroxisome Proliferator-Activated Receptors in HCV-Related Infection
title_full Peroxisome Proliferator-Activated Receptors in HCV-Related Infection
title_fullStr Peroxisome Proliferator-Activated Receptors in HCV-Related Infection
title_full_unstemmed Peroxisome Proliferator-Activated Receptors in HCV-Related Infection
title_short Peroxisome Proliferator-Activated Receptors in HCV-Related Infection
title_sort peroxisome proliferator-activated receptors in hcv-related infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662434/
https://www.ncbi.nlm.nih.gov/pubmed/19343188
http://dx.doi.org/10.1155/2009/357204
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