Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B(1)

The objective of the present study was to evaluate sphingolipid levels (sphingosine-So and sphinganine-Sa) and to compare the Sa/So ratio in liver, serum and urine of Wistar rats after prolonged administration (21 days) of fumonisin B(1) (FB(1)). In parallel, the kinetics of sphingolipid elimination...

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Autores principales: Direito, Glória M., Almeida, Adriana P., Aquino, Simone, dos Reis, Tatiana Alves, Pozzi, Claudia Rodrigues, Corrêa, Benedito
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662460/
https://www.ncbi.nlm.nih.gov/pubmed/19333435
http://dx.doi.org/10.3390/ijms10010050
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author Direito, Glória M.
Almeida, Adriana P.
Aquino, Simone
dos Reis, Tatiana Alves
Pozzi, Claudia Rodrigues
Corrêa, Benedito
author_facet Direito, Glória M.
Almeida, Adriana P.
Aquino, Simone
dos Reis, Tatiana Alves
Pozzi, Claudia Rodrigues
Corrêa, Benedito
author_sort Direito, Glória M.
collection PubMed
description The objective of the present study was to evaluate sphingolipid levels (sphingosine-So and sphinganine-Sa) and to compare the Sa/So ratio in liver, serum and urine of Wistar rats after prolonged administration (21 days) of fumonisin B(1) (FB(1)). In parallel, the kinetics of sphingolipid elimination in urine was studied in animals receiving a single dose of FB(1). Prolonged exposure to FB(1) caused an increase in Sa levels in urine, serum and liver. The most marked effect on sphingolipid biosynthesis was observed in animals treated with the highest dose of FB(1). Animals receiving a single dose of FB(1) presented variations in Sa and So levels and in the Sa/So ratio.
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spelling pubmed-26624602009-03-30 Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B(1) Direito, Glória M. Almeida, Adriana P. Aquino, Simone dos Reis, Tatiana Alves Pozzi, Claudia Rodrigues Corrêa, Benedito Int J Mol Sci Article The objective of the present study was to evaluate sphingolipid levels (sphingosine-So and sphinganine-Sa) and to compare the Sa/So ratio in liver, serum and urine of Wistar rats after prolonged administration (21 days) of fumonisin B(1) (FB(1)). In parallel, the kinetics of sphingolipid elimination in urine was studied in animals receiving a single dose of FB(1). Prolonged exposure to FB(1) caused an increase in Sa levels in urine, serum and liver. The most marked effect on sphingolipid biosynthesis was observed in animals treated with the highest dose of FB(1). Animals receiving a single dose of FB(1) presented variations in Sa and So levels and in the Sa/So ratio. Molecular Diversity Preservation International (MDPI) 2008-12-27 /pmc/articles/PMC2662460/ /pubmed/19333435 http://dx.doi.org/10.3390/ijms10010050 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Direito, Glória M.
Almeida, Adriana P.
Aquino, Simone
dos Reis, Tatiana Alves
Pozzi, Claudia Rodrigues
Corrêa, Benedito
Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B(1)
title Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B(1)
title_full Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B(1)
title_fullStr Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B(1)
title_full_unstemmed Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B(1)
title_short Evaluation of Sphingolipids in Wistar Rats Treated to Prolonged and Single Oral Doses of Fumonisin B(1)
title_sort evaluation of sphingolipids in wistar rats treated to prolonged and single oral doses of fumonisin b(1)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662460/
https://www.ncbi.nlm.nih.gov/pubmed/19333435
http://dx.doi.org/10.3390/ijms10010050
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