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The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link?
Oxidative stress is regarded as a pathogenic factor in hyperthyroidism. Our purpose was to determine the relationship between the oxidative stress and the inflammatory cytokines and to investigate how melatonin affects oxidative damage and cytokine response in thyrotoxic rats. Twenty-one rats were d...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662508/ https://www.ncbi.nlm.nih.gov/pubmed/19343192 http://dx.doi.org/10.1155/2009/391682 |
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author | Makay, Balahan Makay, Ozer Yenisey, Cigdem Icoz, Gokhan Ozgen, Gokhan Unsal, Erbil Akyildiz, Mahir Yetkin, Enis |
author_facet | Makay, Balahan Makay, Ozer Yenisey, Cigdem Icoz, Gokhan Ozgen, Gokhan Unsal, Erbil Akyildiz, Mahir Yetkin, Enis |
author_sort | Makay, Balahan |
collection | PubMed |
description | Oxidative stress is regarded as a pathogenic factor in hyperthyroidism. Our purpose was to determine the relationship between the oxidative stress and the inflammatory cytokines and to investigate how melatonin affects oxidative damage and cytokine response in thyrotoxic rats. Twenty-one rats were divided into three groups. Group A served as negative controls. Group B had untreated thyrotoxicosis, and Group C received melatonin. Serum malondialdehyde (MDA), glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), and nitric oxide derivates (NO(•)x), and plasma IL-6, IL-10, and TNF-alpha were measured. MDA, GSH, NO(•)x, IL-10, and TNF-alpha levels increased after L-thyroxine induction. An inhibition of triiodothyronine and thyroxine was detected, as a result of melatonin administration. MDA, GSH, and NO(•)x levels were also affected by melatonin. Lowest TNF-alpha levels were observed in Group C. This study demonstrates that oxidative stress is related to cytokine response in the thyrotoxic rat. Melatonin treatment suppresses the hyperthyroidism-induced oxidative damage as well as TNF-alpha response. |
format | Text |
id | pubmed-2662508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-26625082009-04-02 The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? Makay, Balahan Makay, Ozer Yenisey, Cigdem Icoz, Gokhan Ozgen, Gokhan Unsal, Erbil Akyildiz, Mahir Yetkin, Enis Mediators Inflamm Research Article Oxidative stress is regarded as a pathogenic factor in hyperthyroidism. Our purpose was to determine the relationship between the oxidative stress and the inflammatory cytokines and to investigate how melatonin affects oxidative damage and cytokine response in thyrotoxic rats. Twenty-one rats were divided into three groups. Group A served as negative controls. Group B had untreated thyrotoxicosis, and Group C received melatonin. Serum malondialdehyde (MDA), glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), and nitric oxide derivates (NO(•)x), and plasma IL-6, IL-10, and TNF-alpha were measured. MDA, GSH, NO(•)x, IL-10, and TNF-alpha levels increased after L-thyroxine induction. An inhibition of triiodothyronine and thyroxine was detected, as a result of melatonin administration. MDA, GSH, and NO(•)x levels were also affected by melatonin. Lowest TNF-alpha levels were observed in Group C. This study demonstrates that oxidative stress is related to cytokine response in the thyrotoxic rat. Melatonin treatment suppresses the hyperthyroidism-induced oxidative damage as well as TNF-alpha response. Hindawi Publishing Corporation 2009 2009-03-30 /pmc/articles/PMC2662508/ /pubmed/19343192 http://dx.doi.org/10.1155/2009/391682 Text en Copyright © 2009 Balahan Makay et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Makay, Balahan Makay, Ozer Yenisey, Cigdem Icoz, Gokhan Ozgen, Gokhan Unsal, Erbil Akyildiz, Mahir Yetkin, Enis The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? |
title | The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? |
title_full | The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? |
title_fullStr | The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? |
title_full_unstemmed | The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? |
title_short | The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? |
title_sort | interaction of oxidative stress response with cytokines in the thyrotoxic rat: is there a link? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662508/ https://www.ncbi.nlm.nih.gov/pubmed/19343192 http://dx.doi.org/10.1155/2009/391682 |
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