Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis

BACKGROUND: In addition to its essential role in ribonucleotide reduction, ribonucleotide reductase (RNR) small subunit, RRM2, has been known to play a critical role in determining tumor malignancy. Overexpression of RRM2 significantly enhances the invasive and metastatic potential of tumor. Angioge...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Keqiang, Hu, Shuya, Wu, Jun, Chen, Linling, Lu, Jianming, Wang, Xiaochen, Liu, Xiyong, Zhou, Bingsen, Yen, Yun
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662784/
https://www.ncbi.nlm.nih.gov/pubmed/19250552
http://dx.doi.org/10.1186/1476-4598-8-11

Ejemplares similares

Ejemplares similares