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Ascorbic acid pre-treated quartz stimulates TNF-α release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxidation
BACKGROUND: Inhalation of crystalline silica induces a pulmonary fibrotic degeneration called silicosis caused by the inability of alveolar macrophages to dissolve the crystalline structure of phagocytosed quartz particles. Ascorbic acid is capable of partially dissolving quartz crystals, leading to...
Autores principales: | Scarfì, Sonia, Magnone, Mirko, Ferraris, Chiara, Pozzolini, Marina, Benvenuto, Federica, Benatti, Umberto, Giovine, Marco |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662810/ https://www.ncbi.nlm.nih.gov/pubmed/19298665 http://dx.doi.org/10.1186/1465-9921-10-25 |
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