High Throughput Functional Assays of the Variant Antigen PfEMP1 Reveal a Single Domain in the 3D7 Plasmodium falciparum Genome that Binds ICAM1 with High Affinity and Is Targeted by Naturally Acquired Neutralizing Antibodies

Plasmodium falciparum–infected erythrocytes bind endothelial receptors to sequester in vascular beds, and binding to ICAM1 has been implicated in cerebral malaria. Binding to ICAM1 may be mediated by the variant surface antigen family PfEMP1: for example, 6 of 21 DBLβC2 domains from the IT4 strain P...

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Detalles Bibliográficos
Autores principales: Oleinikov, Andrew V., Amos, Emily, Frye, Isaac Tyler, Rossnagle, Eddie, Mutabingwa, Theonest K., Fried, Michal, Duffy, Patrick E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663049/
https://www.ncbi.nlm.nih.gov/pubmed/19381252
http://dx.doi.org/10.1371/journal.ppat.1000386

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