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Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling

When modeling cell signaling networks, a balance must be struck between mechanistic detail and ease of interpretation. In this paper we apply a fuzzy logic framework to the analysis of a large, systematic dataset describing the dynamics of cell signaling downstream of TNF, EGF, and insulin receptors...

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Detalles Bibliográficos
Autores principales: Aldridge, Bree B., Saez-Rodriguez, Julio, Muhlich, Jeremy L., Sorger, Peter K., Lauffenburger, Douglas A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663056/
https://www.ncbi.nlm.nih.gov/pubmed/19343194
http://dx.doi.org/10.1371/journal.pcbi.1000340