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Virulence evolution in response to vaccination: The case of malaria

One theory of why some pathogens are virulent (i.e., they damage their host) is that they need to extract resources from their host in order to compete for transmission to new hosts, and this resource extraction can damage the host. Here we describe our studies in malaria that test and support this...

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Detalles Bibliográficos
Autores principales: Mackinnon, M.J., Gandon, S., Read, A.F.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663389/
https://www.ncbi.nlm.nih.gov/pubmed/18773536
http://dx.doi.org/10.1016/j.vaccine.2008.04.012
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author Mackinnon, M.J.
Gandon, S.
Read, A.F.
author_facet Mackinnon, M.J.
Gandon, S.
Read, A.F.
author_sort Mackinnon, M.J.
collection PubMed
description One theory of why some pathogens are virulent (i.e., they damage their host) is that they need to extract resources from their host in order to compete for transmission to new hosts, and this resource extraction can damage the host. Here we describe our studies in malaria that test and support this idea. We go on to show that host immunity can exacerbate selection for virulence and therefore that vaccines that reduce pathogen replication may select for more virulent pathogens, eroding the benefits of vaccination and putting the unvaccinated at greater risk. We suggest that in disease contexts where wild-type parasites can be transmitted through vaccinated hosts, evolutionary outcomes need to be considered.
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spelling pubmed-26633892009-03-31 Virulence evolution in response to vaccination: The case of malaria Mackinnon, M.J. Gandon, S. Read, A.F. Vaccine Article One theory of why some pathogens are virulent (i.e., they damage their host) is that they need to extract resources from their host in order to compete for transmission to new hosts, and this resource extraction can damage the host. Here we describe our studies in malaria that test and support this idea. We go on to show that host immunity can exacerbate selection for virulence and therefore that vaccines that reduce pathogen replication may select for more virulent pathogens, eroding the benefits of vaccination and putting the unvaccinated at greater risk. We suggest that in disease contexts where wild-type parasites can be transmitted through vaccinated hosts, evolutionary outcomes need to be considered. Elsevier Science 2008-07-18 /pmc/articles/PMC2663389/ /pubmed/18773536 http://dx.doi.org/10.1016/j.vaccine.2008.04.012 Text en © 2008 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Mackinnon, M.J.
Gandon, S.
Read, A.F.
Virulence evolution in response to vaccination: The case of malaria
title Virulence evolution in response to vaccination: The case of malaria
title_full Virulence evolution in response to vaccination: The case of malaria
title_fullStr Virulence evolution in response to vaccination: The case of malaria
title_full_unstemmed Virulence evolution in response to vaccination: The case of malaria
title_short Virulence evolution in response to vaccination: The case of malaria
title_sort virulence evolution in response to vaccination: the case of malaria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663389/
https://www.ncbi.nlm.nih.gov/pubmed/18773536
http://dx.doi.org/10.1016/j.vaccine.2008.04.012
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