Hemoglobin Cleavage Site-Specificity of the Plasmodium falciparum Cysteine Proteases Falcipain-2 and Falcipain-3

The Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3 degrade host hemoglobin to provide free amino acids for parasite protein synthesis. Hemoglobin hydrolysis has been described as an ordered process initiated by aspartic proteases, but cysteine protease inhibitors completely blo...

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Detalles Bibliográficos
Autores principales: Subramanian, Shoba, Hardt, Markus, Choe, Youngchool, Niles, Richard K., Johansen, Eric B., Legac, Jennifer, Gut, Jiri, Kerr, Iain D., Craik, Charles S., Rosenthal, Philip J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663817/
https://www.ncbi.nlm.nih.gov/pubmed/19357776
http://dx.doi.org/10.1371/journal.pone.0005156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663817/
https://www.ncbi.nlm.nih.gov/pubmed/19357776
http://dx.doi.org/10.1371/journal.pone.0005156

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