Cargando…

Hemoglobin Cleavage Site-Specificity of the Plasmodium falciparum Cysteine Proteases Falcipain-2 and Falcipain-3

The Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3 degrade host hemoglobin to provide free amino acids for parasite protein synthesis. Hemoglobin hydrolysis has been described as an ordered process initiated by aspartic proteases, but cysteine protease inhibitors completely blo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Subramanian, Shoba, Hardt, Markus, Choe, Youngchool, Niles, Richard K., Johansen, Eric B., Legac, Jennifer, Gut, Jiri, Kerr, Iain D., Craik, Charles S., Rosenthal, Philip J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663817/ https://www.ncbi.nlm.nih.gov/pubmed/19357776 http://dx.doi.org/10.1371/journal.pone.0005156

Ejemplares similares

Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity
por: Kerr, Iain D., et al.
Publicado: (2009)

Structure-Function of Falcipains: Malarial Cysteine Proteases
por: Pandey, Kailash C., et al.
Publicado: (2012)

Regulatory Elements within the Prodomain of Falcipain-2, a Cysteine Protease of the Malaria Parasite Plasmodium falciparum
por: Pandey, Kailash C., et al.
Publicado: (2009)

Distinct and stage specific nuclear factors regulate the expression of falcipains, Plasmodium falciparum cysteine proteases
por: Sunil, Sujatha, et al.
Publicado: (2008)

Microsecond-long simulation reveals the molecular mechanism for the dual inhibition of falcipain-2 and falcipain-3 by antimalarial lead compounds
por: Danazumi, Ammar Usman, et al.
Publicado: (2022)

Quinoline-triazole hybrids inhibit falcipain-2 and arrest the development of Plasmodium falciparum at the trophozoite stage
por: Singh, Anju, et al.
Publicado: (2019)

Polymorphisms in K13 and Falcipain-2 Associated with Artemisinin Resistance Are Not Prevalent in Plasmodium falciparum Isolated from Ugandan Children
por: Conrad, Melissa D., et al.
Publicado: (2014)

Virtual design of novel Plasmodium falciparum cysteine protease falcipain-2 hybrid lactone–chalcone and isatin–chalcone inhibitors probing the S2 active site pocket
por: Allangba, Koffi N’Guessan Placide Gabin, et al.
Publicado: (2019)

Falcipain 2 inhibitors and antiplasmodial compounds from a bio-guided fractionation of the fruits of Sorindeia juglandifolia A. Rich. (Anacardiaceae) growing in Cameroon
por: Boyom, Fabrice F, et al.
Publicado: (2010)

The complex of Plasmodium falciparum falcipain-2 protease with an (E)-chalcone-based inhibitor highlights a novel, small, molecule-binding site
por: Machin, Jonathan M., et al.
Publicado: (2019)

In Silico Study Reveals How E64 Approaches, Binds to, and Inhibits Falcipain-2 of Plasmodium falciparum that Causes Malaria in Humans
por: Salawu, Emmanuel Oluwatobi
Publicado: (2018)

In silico Guided Drug Repurposing: Discovery of New Competitive and Non-competitive Inhibitors of Falcipain-2
por: Alberca, Lucas N., et al.
Publicado: (2019)

Bovipain-2, the falcipain-2 ortholog, is expressed in intraerythrocytic stages of the tick-transmitted hemoparasite Babesia bovis
por: Mesplet, María, et al.
Publicado: (2010)

Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites
por: Hopp, Christine S., et al.
Publicado: (2017)

Allosteric pockets and dynamic residue network hubs of falcipain 2 in mutations including those linked to artemisinin resistance
por: Okeke, Chiamaka Jessica, et al.
Publicado: (2021)

Identification of Potential Antimalarial Drug Candidates Targeting Falcipain-2 Protein of Malaria Parasite—A Computational Strategy
por: Nema, Shrikant, et al.
Publicado: (2022)

Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design
por: Musyoka, Thommas Mutemi, et al.
Publicado: (2019)

Mechanism of falcipain-2 inhibition by α,β-unsaturated benzo[1,4]diazepin-2-one methyl ester
por: Grazioso, Giovanni, et al.
Publicado: (2012)

Target-Based Virtual Screening of Natural Compounds Identifies a Potent Antimalarial With Selective Falcipain-2 Inhibitory Activity
por: Uddin, Amad, et al.
Publicado: (2022)

Design, molecular docking, drug-likeness, and molecular dynamics studies of 1,2,4-trioxane derivatives as novel Plasmodium falciparum falcipain-2 (FP-2) inhibitors
por: Ghosh, Subham, et al.
Publicado: (2021)

Identification of Tight-Binding Plasmepsin II and Falcipain 2 Inhibitors in Aqueous Extracts of Marine Invertebrates by the Combination of Enzymatic and Interaction-Based Assays
por: Salas-Sarduy, Emir, et al.
Publicado: (2017)

In silico investigation of falcipain-2 inhibition by hybrid benzimidazole-thiosemicarbazone antiplasmodial agents: A molecular docking, molecular dynamics simulation, and kinetics study
por: Nkungli, Nyiang Kennet, et al.
Publicado: (2023)

Antimalarial Activity of 4-Metoxychalcones: Docking Studies as Falcipain/Plasmepsin Inhibitors, ADMET and Lipophilic Efficiency Analysis to Identify a Putative Oral Lead Candidate
por: de Oliveira, Michael Eder, et al.
Publicado: (2013)

Biochemical Properties of a Novel Cysteine Protease of Plasmodium vivax, Vivapain-4
por: Na, Byoung-Kuk, et al.
Publicado: (2010)

A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition
por: O'Brien, Theresa C., et al.
Publicado: (2008)

2-(3,4-Dihydro-4-Oxothieno[2,3-d]pyrimidin-2-ylthio) Acetamides as a New Class of Falcipain-2 Inhibitors. 3. Design, Synthesis and Biological Evaluation
por: Zhu, Jin, et al.
Publicado: (2009)

2-Amido-3-(1H-Indol-3-yl)-N-Substitued-Propanamides as a New Class of Falcipain-2 Inhibitors. 1. Design, Synthesis, Biological Evaluation and Binding Model Studies
por: Zhu, Jin, et al.
Publicado: (2009)

Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid
por: Dude, Marie-Adrienne, et al.
Publicado: (2008)

Blocking Plasmodium falciparum Development via Dual Inhibition of Hemoglobin Degradation and the Ubiquitin Proteasome System by MG132
por: Prasad, Rajesh, et al.
Publicado: (2013)

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
por: Sonoiki, Ebere, et al.
Publicado: (2017)

X-ray Structure Determination, Antioxidant Voltammetry Studies of Butein and 2′,4′-Dihydroxy-3,4-dimethoxychalcone. Computational Studies of 4 Structurally Related 2′,4′-diOH Chalcones to Examine Their Antimalarial Activity by Binding to Falcipain-2
por: Okoye, Ijeoma, et al.
Publicado: (2021)

Falstatin, a Cysteine Protease Inhibitor of Plasmodium falciparum, Facilitates Erythrocyte Invasion
por: Pandey, Kailash C, et al.
Publicado: (2006)

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum
por: Yamthe, Lauve Rachel Tchokouaha, et al.
Publicado: (2015)

Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection
por: Sumitomo, Tomoko, et al.
Publicado: (2018)

The Ionic and Hydrophobic Interactions Are Required for the Auto Activation of Cysteine Proteases of Plasmodium falciparum
por: Sundararaj, Srinivasan, et al.
Publicado: (2012)

Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum
por: Duvalsaint, Marvin, et al.
Publicado: (2021)

Cleavage of a carbon–fluorine bond by an engineered cysteine dioxygenase
por: Li, Jiasong, et al.
Publicado: (2018)

Cysteine proteases in protozoan parasites
por: Siqueira-Neto, Jair L., et al.
Publicado: (2018)

Crystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma brucei
por: Kerr, Iain D., et al.
Publicado: (2010)

Identification of Cleavage Sites Recognized by the 3C-Like Cysteine Protease within the Two Polyproteins of Strawberry Mottle Virus
por: Mann, Krin S., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_4il13o9j4289cshvp35c3hmeuu