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Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats?
OBJECTIVE: To evaluate the effects of estrogen treatment in combination with gestrinone on an experimental rat model of endometriosis. METHODS: Uterine transplants were attached to the peritoneum of female Wistar rats via a surgical autotransplantation technique. The implanted area was measured duri...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664131/ https://www.ncbi.nlm.nih.gov/pubmed/18719766 http://dx.doi.org/10.1590/S1807-59322008000400019 |
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author | Lobo, Vera Lúcia Rodrigues Júnior, José Maria Soares de Jesus Simões, Manuel dos Santos Simões, Ricardo de Lima, Geraldo Rodrigues Baracat, Edmund C |
author_facet | Lobo, Vera Lúcia Rodrigues Júnior, José Maria Soares de Jesus Simões, Manuel dos Santos Simões, Ricardo de Lima, Geraldo Rodrigues Baracat, Edmund C |
author_sort | Lobo, Vera Lúcia Rodrigues |
collection | PubMed |
description | OBJECTIVE: To evaluate the effects of estrogen treatment in combination with gestrinone on an experimental rat model of endometriosis. METHODS: Uterine transplants were attached to the peritoneum of female Wistar rats via a surgical autotransplantation technique. The implanted area was measured during the proestrus phase and after hormonal treatment. We performed morphometric analysis and examined the macroscopic and morphometric alterations of endometrial implants after hormonal treatment in ovariectomized rats. RESULTS: The high dose of estrogen caused macroscopic increases in the endometrial implant group compared with other groups, which were similar to increases in the proestrus phase. The low dose showed morphometric development of implants, such as an increase in number of endometrial glands, leukocyte infiltration and mitosis. Gestrinone antagonized both doses of estrogen. CONCLUSION: Our findings suggest that gestrinone antagonizes estrogen’s effects on rat peritoneal endometrial implants. |
format | Text |
id | pubmed-2664131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-26641312009-05-13 Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats? Lobo, Vera Lúcia Rodrigues Júnior, José Maria Soares de Jesus Simões, Manuel dos Santos Simões, Ricardo de Lima, Geraldo Rodrigues Baracat, Edmund C Clinics Basic Research OBJECTIVE: To evaluate the effects of estrogen treatment in combination with gestrinone on an experimental rat model of endometriosis. METHODS: Uterine transplants were attached to the peritoneum of female Wistar rats via a surgical autotransplantation technique. The implanted area was measured during the proestrus phase and after hormonal treatment. We performed morphometric analysis and examined the macroscopic and morphometric alterations of endometrial implants after hormonal treatment in ovariectomized rats. RESULTS: The high dose of estrogen caused macroscopic increases in the endometrial implant group compared with other groups, which were similar to increases in the proestrus phase. The low dose showed morphometric development of implants, such as an increase in number of endometrial glands, leukocyte infiltration and mitosis. Gestrinone antagonized both doses of estrogen. CONCLUSION: Our findings suggest that gestrinone antagonizes estrogen’s effects on rat peritoneal endometrial implants. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2008-08 /pmc/articles/PMC2664131/ /pubmed/18719766 http://dx.doi.org/10.1590/S1807-59322008000400019 Text en Copyright © 2008 Hospital das Clínicas da FMUSP |
spellingShingle | Basic Research Lobo, Vera Lúcia Rodrigues Júnior, José Maria Soares de Jesus Simões, Manuel dos Santos Simões, Ricardo de Lima, Geraldo Rodrigues Baracat, Edmund C Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats? |
title | Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats? |
title_full | Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats? |
title_fullStr | Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats? |
title_full_unstemmed | Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats? |
title_short | Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats? |
title_sort | does gestrinone antagonize the effects of estrogen on endometrial implants upon the peritoneum of rats? |
topic | Basic Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664131/ https://www.ncbi.nlm.nih.gov/pubmed/18719766 http://dx.doi.org/10.1590/S1807-59322008000400019 |
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