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Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats?

OBJECTIVE: To evaluate the effects of estrogen treatment in combination with gestrinone on an experimental rat model of endometriosis. METHODS: Uterine transplants were attached to the peritoneum of female Wistar rats via a surgical autotransplantation technique. The implanted area was measured duri...

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Autores principales: Lobo, Vera Lúcia Rodrigues, Júnior, José Maria Soares, de Jesus Simões, Manuel, dos Santos Simões, Ricardo, de Lima, Geraldo Rodrigues, Baracat, Edmund C
Formato: Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664131/
https://www.ncbi.nlm.nih.gov/pubmed/18719766
http://dx.doi.org/10.1590/S1807-59322008000400019
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author Lobo, Vera Lúcia Rodrigues
Júnior, José Maria Soares
de Jesus Simões, Manuel
dos Santos Simões, Ricardo
de Lima, Geraldo Rodrigues
Baracat, Edmund C
author_facet Lobo, Vera Lúcia Rodrigues
Júnior, José Maria Soares
de Jesus Simões, Manuel
dos Santos Simões, Ricardo
de Lima, Geraldo Rodrigues
Baracat, Edmund C
author_sort Lobo, Vera Lúcia Rodrigues
collection PubMed
description OBJECTIVE: To evaluate the effects of estrogen treatment in combination with gestrinone on an experimental rat model of endometriosis. METHODS: Uterine transplants were attached to the peritoneum of female Wistar rats via a surgical autotransplantation technique. The implanted area was measured during the proestrus phase and after hormonal treatment. We performed morphometric analysis and examined the macroscopic and morphometric alterations of endometrial implants after hormonal treatment in ovariectomized rats. RESULTS: The high dose of estrogen caused macroscopic increases in the endometrial implant group compared with other groups, which were similar to increases in the proestrus phase. The low dose showed morphometric development of implants, such as an increase in number of endometrial glands, leukocyte infiltration and mitosis. Gestrinone antagonized both doses of estrogen. CONCLUSION: Our findings suggest that gestrinone antagonizes estrogen’s effects on rat peritoneal endometrial implants.
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spelling pubmed-26641312009-05-13 Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats? Lobo, Vera Lúcia Rodrigues Júnior, José Maria Soares de Jesus Simões, Manuel dos Santos Simões, Ricardo de Lima, Geraldo Rodrigues Baracat, Edmund C Clinics Basic Research OBJECTIVE: To evaluate the effects of estrogen treatment in combination with gestrinone on an experimental rat model of endometriosis. METHODS: Uterine transplants were attached to the peritoneum of female Wistar rats via a surgical autotransplantation technique. The implanted area was measured during the proestrus phase and after hormonal treatment. We performed morphometric analysis and examined the macroscopic and morphometric alterations of endometrial implants after hormonal treatment in ovariectomized rats. RESULTS: The high dose of estrogen caused macroscopic increases in the endometrial implant group compared with other groups, which were similar to increases in the proestrus phase. The low dose showed morphometric development of implants, such as an increase in number of endometrial glands, leukocyte infiltration and mitosis. Gestrinone antagonized both doses of estrogen. CONCLUSION: Our findings suggest that gestrinone antagonizes estrogen’s effects on rat peritoneal endometrial implants. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2008-08 /pmc/articles/PMC2664131/ /pubmed/18719766 http://dx.doi.org/10.1590/S1807-59322008000400019 Text en Copyright © 2008 Hospital das Clínicas da FMUSP
spellingShingle Basic Research
Lobo, Vera Lúcia Rodrigues
Júnior, José Maria Soares
de Jesus Simões, Manuel
dos Santos Simões, Ricardo
de Lima, Geraldo Rodrigues
Baracat, Edmund C
Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats?
title Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats?
title_full Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats?
title_fullStr Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats?
title_full_unstemmed Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats?
title_short Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats?
title_sort does gestrinone antagonize the effects of estrogen on endometrial implants upon the peritoneum of rats?
topic Basic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664131/
https://www.ncbi.nlm.nih.gov/pubmed/18719766
http://dx.doi.org/10.1590/S1807-59322008000400019
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