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Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity
Individual diversity at the major histocompatibility complex (MHC) is predicted to be optimal at intermediate rather than at maximal levels. We showed previously in sticklebacks that an intermediate MHC diversity is predominant in natural populations and provides maximal resistance in experimental m...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664370/ https://www.ncbi.nlm.nih.gov/pubmed/19033141 http://dx.doi.org/10.1098/rspb.2008.1466 |
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author | Kalbe, Martin Eizaguirre, Christophe Dankert, Ilka Reusch, Thorsten B.H. Sommerfeld, Ralf D. Wegner, K. Mathias Milinski, Manfred |
author_facet | Kalbe, Martin Eizaguirre, Christophe Dankert, Ilka Reusch, Thorsten B.H. Sommerfeld, Ralf D. Wegner, K. Mathias Milinski, Manfred |
author_sort | Kalbe, Martin |
collection | PubMed |
description | Individual diversity at the major histocompatibility complex (MHC) is predicted to be optimal at intermediate rather than at maximal levels. We showed previously in sticklebacks that an intermediate MHC diversity is predominant in natural populations and provides maximal resistance in experimental multiple parasite infections in the laboratory. However, what counts ultimately is the lifetime reproductive success (LRS). Here, we measured LRS of six laboratory-bred sib-groups—to minimize the influence of non-MHC genes—three-spined sticklebacks (Gasterosteus aculeatus) during their entire breeding period, each in a seminatural enclosure in the lake of their parents, where they were exposed to the natural spectrum of parasites. We collected developing clutches at regular intervals and determined parenthood for a representative number of eggs (2279 in total) per clutch with 18 microsatellites. Both males and females with an intermediate MHC class IIB variant number had the highest LRS. The mechanistic link of MHC diversity and LRS differed between the sexes: in females, we found evidence for a trade-off between number of eggs and immunocompentence, whereas in males this correlation was concealed by different timing strategies of reproduction. |
format | Text |
id | pubmed-2664370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-26643702009-04-13 Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity Kalbe, Martin Eizaguirre, Christophe Dankert, Ilka Reusch, Thorsten B.H. Sommerfeld, Ralf D. Wegner, K. Mathias Milinski, Manfred Proc Biol Sci Research Article Individual diversity at the major histocompatibility complex (MHC) is predicted to be optimal at intermediate rather than at maximal levels. We showed previously in sticklebacks that an intermediate MHC diversity is predominant in natural populations and provides maximal resistance in experimental multiple parasite infections in the laboratory. However, what counts ultimately is the lifetime reproductive success (LRS). Here, we measured LRS of six laboratory-bred sib-groups—to minimize the influence of non-MHC genes—three-spined sticklebacks (Gasterosteus aculeatus) during their entire breeding period, each in a seminatural enclosure in the lake of their parents, where they were exposed to the natural spectrum of parasites. We collected developing clutches at regular intervals and determined parenthood for a representative number of eggs (2279 in total) per clutch with 18 microsatellites. Both males and females with an intermediate MHC class IIB variant number had the highest LRS. The mechanistic link of MHC diversity and LRS differed between the sexes: in females, we found evidence for a trade-off between number of eggs and immunocompentence, whereas in males this correlation was concealed by different timing strategies of reproduction. The Royal Society 2008-11-25 2009-03-07 /pmc/articles/PMC2664370/ /pubmed/19033141 http://dx.doi.org/10.1098/rspb.2008.1466 Text en Copyright © 2008 The Royal Society http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kalbe, Martin Eizaguirre, Christophe Dankert, Ilka Reusch, Thorsten B.H. Sommerfeld, Ralf D. Wegner, K. Mathias Milinski, Manfred Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity |
title | Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity |
title_full | Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity |
title_fullStr | Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity |
title_full_unstemmed | Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity |
title_short | Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity |
title_sort | lifetime reproductive success is maximized with optimal major histocompatibility complex diversity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664370/ https://www.ncbi.nlm.nih.gov/pubmed/19033141 http://dx.doi.org/10.1098/rspb.2008.1466 |
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