Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

Mutations in the progranulin gene (GRN) are an important cause of frontotemporal lobar degeneration (FTLD) with ubiquitin and TAR DNA-binding protein 43 (TDP43)-positive pathology. The clinical presentation associated with GRN mutations is heterogeneous and may include clinical probable Alzheimer�...

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Detalles Bibliográficos
Autores principales: Finch, NiCole, Baker, Matt, Crook, Richard, Swanson, Katie, Kuntz, Karen, Surtees, Rebecca, Bisceglio, Gina, Rovelet-Lecrux, Anne, Boeve, Bradley, Petersen, Ronald C., Dickson, Dennis W., Younkin, Steven G., Deramecourt, Vincent, Crook, Julia, Graff-Radford, Neill R., Rademakers, Rosa
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664450/
https://www.ncbi.nlm.nih.gov/pubmed/19158106
http://dx.doi.org/10.1093/brain/awn352

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