Cargando…

A Novel Information Retrieval Model for High-Throughput Molecular Medicine Modalities

Significant research has been devoted to predicting diagnosis, prognosis, and response to treatment using high-throughput assays. Rapid translation into clinical results hinges upon efficient access to up-to-date and high-quality molecular medicine modalities. We first explain why this goal is inade...

Descripción completa

Detalles Bibliográficos
Autores principales: Wehbe, Firas H., Brown, Steven H., Massion, Pierre P., Gadd, Cynthia S., Masys, Daniel R., Aliferis, Constantin F.
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664697/
https://www.ncbi.nlm.nih.gov/pubmed/19458790
_version_ 1782165979062599680
author Wehbe, Firas H.
Brown, Steven H.
Massion, Pierre P.
Gadd, Cynthia S.
Masys, Daniel R.
Aliferis, Constantin F.
author_facet Wehbe, Firas H.
Brown, Steven H.
Massion, Pierre P.
Gadd, Cynthia S.
Masys, Daniel R.
Aliferis, Constantin F.
author_sort Wehbe, Firas H.
collection PubMed
description Significant research has been devoted to predicting diagnosis, prognosis, and response to treatment using high-throughput assays. Rapid translation into clinical results hinges upon efficient access to up-to-date and high-quality molecular medicine modalities. We first explain why this goal is inadequately supported by existing databases and portals and then introduce a novel semantic indexing and information retrieval model for clinical bioinformatics. The formalism provides the means for indexing a variety of relevant objects (e.g. papers, algorithms, signatures, datasets) and includes a model of the research processes that creates and validates these objects in order to support their systematic presentation once retrieved. We test the applicability of the model by constructing proof-of-concept encodings and visual presentations of evidence and modalities in molecular profiling and prognosis of: (a) diffuse large B-cell lymphoma (DLBCL) and (b) breast cancer.
format Text
id pubmed-2664697
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Libertas Academica
record_format MEDLINE/PubMed
spelling pubmed-26646972009-05-20 A Novel Information Retrieval Model for High-Throughput Molecular Medicine Modalities Wehbe, Firas H. Brown, Steven H. Massion, Pierre P. Gadd, Cynthia S. Masys, Daniel R. Aliferis, Constantin F. Cancer Inform Methodology Significant research has been devoted to predicting diagnosis, prognosis, and response to treatment using high-throughput assays. Rapid translation into clinical results hinges upon efficient access to up-to-date and high-quality molecular medicine modalities. We first explain why this goal is inadequately supported by existing databases and portals and then introduce a novel semantic indexing and information retrieval model for clinical bioinformatics. The formalism provides the means for indexing a variety of relevant objects (e.g. papers, algorithms, signatures, datasets) and includes a model of the research processes that creates and validates these objects in order to support their systematic presentation once retrieved. We test the applicability of the model by constructing proof-of-concept encodings and visual presentations of evidence and modalities in molecular profiling and prognosis of: (a) diffuse large B-cell lymphoma (DLBCL) and (b) breast cancer. Libertas Academica 2009-02-09 /pmc/articles/PMC2664697/ /pubmed/19458790 Text en © 2009 The authors. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Methodology
Wehbe, Firas H.
Brown, Steven H.
Massion, Pierre P.
Gadd, Cynthia S.
Masys, Daniel R.
Aliferis, Constantin F.
A Novel Information Retrieval Model for High-Throughput Molecular Medicine Modalities
title A Novel Information Retrieval Model for High-Throughput Molecular Medicine Modalities
title_full A Novel Information Retrieval Model for High-Throughput Molecular Medicine Modalities
title_fullStr A Novel Information Retrieval Model for High-Throughput Molecular Medicine Modalities
title_full_unstemmed A Novel Information Retrieval Model for High-Throughput Molecular Medicine Modalities
title_short A Novel Information Retrieval Model for High-Throughput Molecular Medicine Modalities
title_sort novel information retrieval model for high-throughput molecular medicine modalities
topic Methodology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664697/
https://www.ncbi.nlm.nih.gov/pubmed/19458790
work_keys_str_mv AT wehbefirash anovelinformationretrievalmodelforhighthroughputmolecularmedicinemodalities
AT brownstevenh anovelinformationretrievalmodelforhighthroughputmolecularmedicinemodalities
AT massionpierrep anovelinformationretrievalmodelforhighthroughputmolecularmedicinemodalities
AT gaddcynthias anovelinformationretrievalmodelforhighthroughputmolecularmedicinemodalities
AT masysdanielr anovelinformationretrievalmodelforhighthroughputmolecularmedicinemodalities
AT aliferisconstantinf anovelinformationretrievalmodelforhighthroughputmolecularmedicinemodalities
AT wehbefirash novelinformationretrievalmodelforhighthroughputmolecularmedicinemodalities
AT brownstevenh novelinformationretrievalmodelforhighthroughputmolecularmedicinemodalities
AT massionpierrep novelinformationretrievalmodelforhighthroughputmolecularmedicinemodalities
AT gaddcynthias novelinformationretrievalmodelforhighthroughputmolecularmedicinemodalities
AT masysdanielr novelinformationretrievalmodelforhighthroughputmolecularmedicinemodalities
AT aliferisconstantinf novelinformationretrievalmodelforhighthroughputmolecularmedicinemodalities