Cargando…

Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model – the Zucker diabetic rat

BACKGROUND: Diabetic cardiomyopathy (DCM) contributes to cardiac failure in diabetic patients. It is characterized by excessive lipids accumulation, with increased triacylglycerol (TAG) stores, and fibrosis in left ventricle (LV). The mechanisms responsible are incompletely known and no specific tre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Forcheron, Fabien, Basset, Alexandra, Abdallah, Pauline, Del Carmine, Peggy, Gadot, Nicolas, Beylot, Michel
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664796/ https://www.ncbi.nlm.nih.gov/pubmed/19317897 http://dx.doi.org/10.1186/1475-2840-8-16

Ejemplares similares

Lipogenesis in arterial wall and vascular smooth muscular cells: regulation and abnormalities in insulin-resistance
por: Hamlat, Nadjiba, et al.
Publicado: (2009)

Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle
por: van den Brom, Charissa E, et al.
Publicado: (2010)

Increased Atherosclerosis in Mice Deficient in Perilipin1
por: Langlois, Dominique, et al.
Publicado: (2011)

Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study: baseline characteristics and short-term effects of fenofibrate [ISRCTN64783481]
Publicado: (2005)

Supplementation with a Cocoa–Carob Blend, Alone or in Combination with Metformin, Attenuates Diabetic Cardiomyopathy, Cardiac Oxidative Stress and Inflammation in Zucker Diabetic Rats
por: García-Díez, Esther, et al.
Publicado: (2022)

Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat
por: VanHoose, Lisa, et al.
Publicado: (2010)

Expression of fourteen novel obesity-related genes in zucker diabetic fatty rats
por: Schmid, Peter M, et al.
Publicado: (2012)

Effect of the combination of metformin and fenofibrate on glucose homeostasis in diabetic Goto-Kakizaki rats
por: Oh, Tae Jung, et al.
Publicado: (2013)

Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats
por: Lu, Xiao, et al.
Publicado: (2010)

Effects of metformin, acarbose, and sitagliptin monotherapy on gut microbiota in Zucker diabetic fatty rats
por: Zhang, Minchun, et al.
Publicado: (2019)

Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats
por: Sui, Yi, et al.
Publicado: (2019)

Myocardial impulse propagation is impaired in right ventricular tissue of Zucker Diabetic Fatty (ZDF) rats
por: Olsen, Kristine Boisen, et al.
Publicado: (2013)

Fenofibrate plus Metformin Produces Cardioprotection in a Type 2 Diabetes and Acute Myocardial Infarction Model
por: Oidor-Chan, Víctor Hugo, et al.
Publicado: (2016)

Eplerenone prevents salt-induced vascular stiffness in Zucker diabetic fatty rats: a preliminary report
por: Resch, Markus, et al.
Publicado: (2011)

Urinary Metabolomic Profiling in Zucker Diabetic Fatty Rats with Type 2 Diabetes Mellitus Treated with Glimepiride, Metformin, and Their Combination
por: Dong, Yu, et al.
Publicado: (2016)

The need for a large-scale trial of fibrate therapy in diabetes: the rationale and design of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. [ISRCTN64783481]
Publicado: (2004)

Coenzyme A and Its Thioester Pools in Obese Zucker and Zucker Diabetic Fatty Rats
por: Chohnan, Shigeru, et al.
Publicado: (2020)

AGEs breaking and antioxidant treatment improves endothelium-dependent dilation without effect on flow-mediated remodeling of resistance arteries in old Zucker diabetic rats
por: Freidja, Mohamed L, et al.
Publicado: (2014)

Chronic NF-κB blockade improves renal angiotensin II type 1 receptor functions and reduces blood pressure in Zucker diabetic rats
por: Luo, Hao, et al.
Publicado: (2015)

Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid
por: Li, Chun-jun, et al.
Publicado: (2012)

Phenotyping diabetic cardiomyopathy in Europeans and South Asians
por: Paiman, Elisabeth H. M., et al.
Publicado: (2019)

Cognitive Performance during the Development of Diabetes in the Zucker Diabetic Fatty Rat
por: Spoelder, Marcia, et al.
Publicado: (2023)

Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats
por: Schmid, Peter M, et al.
Publicado: (2013)

Pleiotropic Action of Short-Term Metformin and Fenofibrate Treatment, Combined With Lifestyle Intervention, in Type 2 Diabetic Patients With Mixed Dyslipidemia
por: Pruski, Maciej, et al.
Publicado: (2009)

Effects of fenofibrate on inflammatory cytokines in diabetic retinopathy patients
por: Ju, Hai-Bing, et al.
Publicado: (2017)

Fenofibrate and Impaired Taste Perception in Type 2 Diabetes
por: Davis, Timothy M.E.
Publicado: (2020)

Therapeutic effects of neuregulin-1 in diabetic cardiomyopathy rats
por: Li, Bingong, et al.
Publicado: (2011)

Histological Evaluation of Diabetic Neurodegeneration in the Retina of Zucker Diabetic Fatty (ZDF) Rats
por: Szabó, Klaudia, et al.
Publicado: (2017)

Fibroblast growth factor-23 is associated with imaging markers of diabetic cardiomyopathy and anti-diabetic therapeutics
por: Sørensen, Martin H., et al.
Publicado: (2020)

Effect of the addition of rosiglitazone to metformin or sulfonylureas versus metformin/sulfonylurea combination therapy on ambulatory blood pressure in people with type 2 diabetes: A randomized controlled trial (the RECORD study)
por: Komajda, Michel, et al.
Publicado: (2008)

Riboflavin alleviates cardiac failure in Type I diabetic cardiomyopathy
por: Wang, Guoguang, et al.
Publicado: (2011)

Progressive decay of Ca(2+) homeostasis in the development of diabetic cardiomyopathy
por: Zhao, Shu-Mei, et al.
Publicado: (2014)

Elevated pulmonary arterial pressure in Zucker diabetic fatty rats
por: Morales-Cano, Daniel, et al.
Publicado: (2019)

Effect of fenofibrate on microcirculation and wound healing in healthy and diabetic mice
por: Valentin, S, et al.
Publicado: (2009)

Should We Start All Patients with Diabetic Retinopathy on Fenofibrates?
por: Koshy, Jacob, et al.
Publicado: (2013)

Fenofibrate improves vascular endothelial function and contractility in diabetic mice
por: Xu, Nan, et al.
Publicado: (2018)

Efficacy of fenofibrate for diabetic retinopathy: A systematic review protocol
por: Su, Xing-jie, et al.
Publicado: (2019)

Fenofibrate decreased microalbuminuria in the type 2 diabetes patients with hypertriglyceridemia
por: Sun, Xiaomeng, et al.
Publicado: (2020)

Diabetic retinopathy is associated with diastolic dysfunction in type 2 diabetic patients with non-ischemic dilated cardiomyopathy
por: Chung, Yoo-Ri, et al.
Publicado: (2017)

Effect of KIOM-79 on Diabetes-Induced Myocardial Fibrosis in Zucker Diabetic Fatty Rats
por: Kim, Junghyun, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ojn7mu9h9v2ldp16srdmi02anl