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Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion

PURPOSE: Branch retinal vein occlusion (BRVO) is a common vision-threatening disease. Compression of the underlying retinal vein due to increased rigidity of the crossing artery has been implicated in the pathogenesis of BRVO. Among others, arterial hypertension and hypercholesterolemia, both of whi...

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Autores principales: Steinbrugger, Iris, Haas, Anton, Maier, Richard, Renner, Wilfried, Mayer, Monika, Werner, Christoph, Wedrich, Andreas, El-Shabrawi, Yosuf, Schmut, Otto, Weger, Martin
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664846/
https://www.ncbi.nlm.nih.gov/pubmed/19347053
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author Steinbrugger, Iris
Haas, Anton
Maier, Richard
Renner, Wilfried
Mayer, Monika
Werner, Christoph
Wedrich, Andreas
El-Shabrawi, Yosuf
Schmut, Otto
Weger, Martin
author_facet Steinbrugger, Iris
Haas, Anton
Maier, Richard
Renner, Wilfried
Mayer, Monika
Werner, Christoph
Wedrich, Andreas
El-Shabrawi, Yosuf
Schmut, Otto
Weger, Martin
author_sort Steinbrugger, Iris
collection PubMed
description PURPOSE: Branch retinal vein occlusion (BRVO) is a common vision-threatening disease. Compression of the underlying retinal vein due to increased rigidity of the crossing artery has been implicated in the pathogenesis of BRVO. Among others, arterial hypertension and hypercholesterolemia, both of which contribute to atherogenesis, have been identified as risk factors. Atherosclerosis itself is a chronic low-grade inflammatory disease with a distinct pro-inflammatory cytokine pattern. In addition to their role in atherogenesis, some cytokines have been shown to exert procoagulatory effects, and may thus contribute to the development of BRVO by a second mechanism. Gene polymorphisms affecting the expression of inflammation-related cytokines are therefore candidates as potential risk factors for BRVO. The purpose of the present study was to investigate hypothesized associations between cytokine gene polymorphisms and the presence of BRVO. METHODS: The study comprised 398 patients with BRVO and 355 control subjects. Using 5′exonuclease assays (TaqMan), genotypes of the following functional single nucleotide polymorphisms were determined: interleukin 1 beta (IL1B) −511C>T, interleukin 1 receptor antagonist (IL1RN) 1018T>C, interleukin 4 (IL4) −584C>T, interleukin 6 (IL6) −174G>C, interleukin 8 (IL8) −251A>T, interleukin 10 (IL10) −592C>A, interleukin 18 (IL18) 183A>G, tumor necrosis factor (TNF) −308G>A, monocyte chemoattractant protein 1 (CCL2) −2518A>G, and RANTES (CCL5) −403G>A. RESULTS: Neither genotype distributions nor allele frequencies of any of the investigated polymorphisms differed significantly between BRVO patients and controls (p>0.05). Arterial hypertension was found to be significantly more prevalent in BRVO patients than in controls (p<0.001). In a logistic regression analysis presence of arterial hypertension was associated with an odds ratio of 3.33 (95% confidence interval: 2.42–4.57) for BRVO. CONCLUSIONS: As none of the investigated gene variants was significantly more prevalent in BRVO patients than among control subjects, our data suggest that these polymorphisms themselves are unlikely major risk factors for BRVO.
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spelling pubmed-26648462009-04-03 Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion Steinbrugger, Iris Haas, Anton Maier, Richard Renner, Wilfried Mayer, Monika Werner, Christoph Wedrich, Andreas El-Shabrawi, Yosuf Schmut, Otto Weger, Martin Mol Vis Research Article PURPOSE: Branch retinal vein occlusion (BRVO) is a common vision-threatening disease. Compression of the underlying retinal vein due to increased rigidity of the crossing artery has been implicated in the pathogenesis of BRVO. Among others, arterial hypertension and hypercholesterolemia, both of which contribute to atherogenesis, have been identified as risk factors. Atherosclerosis itself is a chronic low-grade inflammatory disease with a distinct pro-inflammatory cytokine pattern. In addition to their role in atherogenesis, some cytokines have been shown to exert procoagulatory effects, and may thus contribute to the development of BRVO by a second mechanism. Gene polymorphisms affecting the expression of inflammation-related cytokines are therefore candidates as potential risk factors for BRVO. The purpose of the present study was to investigate hypothesized associations between cytokine gene polymorphisms and the presence of BRVO. METHODS: The study comprised 398 patients with BRVO and 355 control subjects. Using 5′exonuclease assays (TaqMan), genotypes of the following functional single nucleotide polymorphisms were determined: interleukin 1 beta (IL1B) −511C>T, interleukin 1 receptor antagonist (IL1RN) 1018T>C, interleukin 4 (IL4) −584C>T, interleukin 6 (IL6) −174G>C, interleukin 8 (IL8) −251A>T, interleukin 10 (IL10) −592C>A, interleukin 18 (IL18) 183A>G, tumor necrosis factor (TNF) −308G>A, monocyte chemoattractant protein 1 (CCL2) −2518A>G, and RANTES (CCL5) −403G>A. RESULTS: Neither genotype distributions nor allele frequencies of any of the investigated polymorphisms differed significantly between BRVO patients and controls (p>0.05). Arterial hypertension was found to be significantly more prevalent in BRVO patients than in controls (p<0.001). In a logistic regression analysis presence of arterial hypertension was associated with an odds ratio of 3.33 (95% confidence interval: 2.42–4.57) for BRVO. CONCLUSIONS: As none of the investigated gene variants was significantly more prevalent in BRVO patients than among control subjects, our data suggest that these polymorphisms themselves are unlikely major risk factors for BRVO. Molecular Vision 2009-03-27 /pmc/articles/PMC2664846/ /pubmed/19347053 Text en http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Steinbrugger, Iris
Haas, Anton
Maier, Richard
Renner, Wilfried
Mayer, Monika
Werner, Christoph
Wedrich, Andreas
El-Shabrawi, Yosuf
Schmut, Otto
Weger, Martin
Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion
title Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion
title_full Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion
title_fullStr Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion
title_full_unstemmed Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion
title_short Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion
title_sort analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664846/
https://www.ncbi.nlm.nih.gov/pubmed/19347053
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