Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway

APE1/Ref-1 is an essential DNA repair/gene regulatory protein in mammals of which intracellular level significantly affects cellular sensitivity to genotoxicants. The APE1 functions are altered by phosphorylation and acetylation. We here report that APE1 is also modified by ubiquitination. APE1 ubiq...

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Detalles Bibliográficos
Autores principales: Busso, Carlos S., Iwakuma, Tomoo, Izumi, Tadahide
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664849/
https://www.ncbi.nlm.nih.gov/pubmed/19219073
http://dx.doi.org/10.1038/onc.2009.5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664849/
https://www.ncbi.nlm.nih.gov/pubmed/19219073
http://dx.doi.org/10.1038/onc.2009.5

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