Mutations in Specific Structural Regions of Immunoglobulin Light Chains Are Associated with Free Light Chain Levels in Patients with AL Amyloidosis

BACKGROUND: The amyloidoses are protein misfolding diseases characterized by the deposition of amyloid that leads to cell death and tissue degeneration. In immunoglobulin light chain amyloidosis (AL), each patient has a unique monoclonal immunoglobulin light chain (LC) that forms amyloid deposits. S...

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Detalles Bibliográficos
Autores principales: Poshusta, Tanya L., Sikkink, Laura A., Leung, Nelson, Clark, Raynell J., Dispenzieri, Angela, Ramirez-Alvarado, Marina
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664898/
https://www.ncbi.nlm.nih.gov/pubmed/19365555
http://dx.doi.org/10.1371/journal.pone.0005169

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