Newly Generated Heparanase Knock-Out Mice Unravel Co-Regulation of Heparanase and Matrix Metalloproteinases

BACKGROUND: Heparanase, a mammalian endo-β-D-glucuronidase, specifically degrades heparan sulfate proteoglycans ubiquitously associated with the cell surface and extracellular matrix. This single gene encoded enzyme is over-expressed in most human cancers, promoting tumor metastasis and angiogenesis...

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Detalles Bibliográficos
Autores principales: Zcharia, Eyal, Jia, Juan, Zhang, Xiao, Baraz, Lea, Lindahl, Ulf, Peretz, Tamar, Vlodavsky, Israel, Li, Jin-Ping
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664924/
https://www.ncbi.nlm.nih.gov/pubmed/19360105
http://dx.doi.org/10.1371/journal.pone.0005181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664924/
https://www.ncbi.nlm.nih.gov/pubmed/19360105
http://dx.doi.org/10.1371/journal.pone.0005181

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