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Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein
During minus-strand DNA synthesis, RNase H degrades viral RNA sequences, generating potential plus-strand DNA primers. However, selection of the 3′ polypurine tract (PPT) as the exclusive primer is required for formation of viral DNA with the correct 5′-end and for subsequent integration. Here we sh...
Autores principales: | Post, Klara, Kankia, Besik, Gopalakrishnan, Swathi, Yang, Victoria, Cramer, Elizabeth, Saladores, Pilar, Gorelick, Robert J., Guo, Jianhui, Musier-Forsyth, Karin, Levin, Judith G. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665208/ https://www.ncbi.nlm.nih.gov/pubmed/19158189 http://dx.doi.org/10.1093/nar/gkn1045 |
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