Functional four-base A/T gap core sequence CATTAG of P53 response elements specifically bound tetrameric P53 differently than two-base A/T gap core sequence CATG bound both dimeric and tetrameric P53

The consensus sequence of p53 is repeated half sites of PuPuPuC(A/T)(A/T)GPyPyPy. GtAGCAttAGCCCAGACATGTCC is a 14-3-3σ promoter p53 regulation site; the first core sequence is CAttAG, and the second is CATG. Both mutants GtAGgAttAGCCCAGACATGTCC and GtAGCAttAGCCCAGACATcTCC can be activated by p53 as...

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Detalles Bibliográficos
Autores principales: Cai, Bi-He, Chen, Jang-Yi, Lu, Mei-Hua, Chang, Li-Tze, Lin, Hwang-Chi, Chang, Yu-Ming, Chao, Chung-Faye
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665222/
https://www.ncbi.nlm.nih.gov/pubmed/19208646
http://dx.doi.org/10.1093/nar/gkp033

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