Regulation of cardiovascular development and integrity by the Heart of Glass-Cerebral Cavernous Malformation pathway

Cerebral cavernous malformations (CCMs) are human vascular malformations caused by mutations in three genes of unknown function, KRIT1, CCM2 and PDCD10. Here we show that the HEG1 receptor, linked to CCM genes in zebrafish, is selectively expressed in endothelial cells and that Heg1(-/-) mice exhibi...

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Detalles Bibliográficos
Autores principales: Kleaveland, Benjamin, Zheng, Xiangjian, Liu, Jian J., Blum, Yannick, Tung, Jennifer J., Zou, Zhiying, Chen, Mei, Guo, Lili, Lu, Min-min, Zhou, Diane, Kitajewski, Jan, Affolter, Markus, Ginsberg, Mark H., Kahn, Mark L.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665266/
https://www.ncbi.nlm.nih.gov/pubmed/19151727
http://dx.doi.org/10.1038/nm.1918

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