HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex

BACKGROUND: V(D)J recombination is initiated in antigen receptor loci by the pairwise cleavage of recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins via a nick-hairpin mechanism. The RSS contains highly conserved heptamer (consensus: 5'-CACAGTG) and nonamer (consensus: 5'-...

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Detalles Bibliográficos
Autores principales: Zhang, Ming, Swanson, Patrick C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666730/
https://www.ncbi.nlm.nih.gov/pubmed/19317908
http://dx.doi.org/10.1186/1471-2199-10-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666730/
https://www.ncbi.nlm.nih.gov/pubmed/19317908
http://dx.doi.org/10.1186/1471-2199-10-24

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