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HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex

BACKGROUND: V(D)J recombination is initiated in antigen receptor loci by the pairwise cleavage of recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins via a nick-hairpin mechanism. The RSS contains highly conserved heptamer (consensus: 5'-CACAGTG) and nonamer (consensus: 5'-...

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Detalles Bibliográficos
Autores principales:	Zhang, Ming, Swanson, Patrick C
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666730/ https://www.ncbi.nlm.nih.gov/pubmed/19317908 http://dx.doi.org/10.1186/1471-2199-10-24

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