Cytotoxic Aaptamines from Malaysian Aaptos aaptos

In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chlor...

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Detalles Bibliográficos
Autores principales: Shaari, Khozirah, Ling, Kee Cheng, Rashid, Zalilawati Mat, Jean, Tan Pei, Abas, Faridah, Raof, Salahudin Mohd., Zainal, Zurina, Lajis, Nordin Hj., Mohamad, Habsah, Ali, Abdul Manaf
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666884/
https://www.ncbi.nlm.nih.gov/pubmed/19370166
http://dx.doi.org/10.3390/md7010001
Descripción
Sumario:In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells.

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