Cytotoxic Aaptamines from Malaysian Aaptos aaptos

In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chlor...

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Autores principales: Shaari, Khozirah, Ling, Kee Cheng, Rashid, Zalilawati Mat, Jean, Tan Pei, Abas, Faridah, Raof, Salahudin Mohd., Zainal, Zurina, Lajis, Nordin Hj., Mohamad, Habsah, Ali, Abdul Manaf
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2008
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666884/
https://www.ncbi.nlm.nih.gov/pubmed/19370166
http://dx.doi.org/10.3390/md7010001
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author Shaari, Khozirah
Ling, Kee Cheng
Rashid, Zalilawati Mat
Jean, Tan Pei
Abas, Faridah
Raof, Salahudin Mohd.
Zainal, Zurina
Lajis, Nordin Hj.
Mohamad, Habsah
Ali, Abdul Manaf
author_facet Shaari, Khozirah
Ling, Kee Cheng
Rashid, Zalilawati Mat
Jean, Tan Pei
Abas, Faridah
Raof, Salahudin Mohd.
Zainal, Zurina
Lajis, Nordin Hj.
Mohamad, Habsah
Ali, Abdul Manaf
author_sort Shaari, Khozirah
collection PubMed
description In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells.
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spelling pubmed-26668842009-04-15 Cytotoxic Aaptamines from Malaysian Aaptos aaptos Shaari, Khozirah Ling, Kee Cheng Rashid, Zalilawati Mat Jean, Tan Pei Abas, Faridah Raof, Salahudin Mohd. Zainal, Zurina Lajis, Nordin Hj. Mohamad, Habsah Ali, Abdul Manaf Mar Drugs Article In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells. Molecular Diversity Preservation International 2008-12-28 /pmc/articles/PMC2666884/ /pubmed/19370166 http://dx.doi.org/10.3390/md7010001 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Shaari, Khozirah
Ling, Kee Cheng
Rashid, Zalilawati Mat
Jean, Tan Pei
Abas, Faridah
Raof, Salahudin Mohd.
Zainal, Zurina
Lajis, Nordin Hj.
Mohamad, Habsah
Ali, Abdul Manaf
Cytotoxic Aaptamines from Malaysian Aaptos aaptos
title Cytotoxic Aaptamines from Malaysian Aaptos aaptos
title_full Cytotoxic Aaptamines from Malaysian Aaptos aaptos
title_fullStr Cytotoxic Aaptamines from Malaysian Aaptos aaptos
title_full_unstemmed Cytotoxic Aaptamines from Malaysian Aaptos aaptos
title_short Cytotoxic Aaptamines from Malaysian Aaptos aaptos
title_sort cytotoxic aaptamines from malaysian aaptos aaptos
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666884/
https://www.ncbi.nlm.nih.gov/pubmed/19370166
http://dx.doi.org/10.3390/md7010001
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