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A Bipolar Clamp Mechanism for Activation of Jak-Family Protein Tyrosine Kinases

Most cell surface receptors for growth factors and cytokines dimerize in order to mediate signal transduction. For many such receptors, the Janus kinase (Jak) family of non-receptor protein tyrosine kinases are recruited in pairs and juxtaposed by dimerized receptor complexes in order to activate on...

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Detalles Bibliográficos
Autores principales: Barua, Dipak, Faeder, James R., Haugh, Jason M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667146/
https://www.ncbi.nlm.nih.gov/pubmed/19381268
http://dx.doi.org/10.1371/journal.pcbi.1000364

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