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Roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart

BACKGROUND: The heart is capable of maintaining contractile function despite a transient decrease in blood flow and increase in cardiac ATP demand during systole. This study analyzes a previously developed model of cardiac energetics and oxygen transport to understand the roles of the creatine kinas...

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Detalles Bibliográficos
Autores principales: Wu, Fan, Beard, Daniel A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667476/
https://www.ncbi.nlm.nih.gov/pubmed/19228404
http://dx.doi.org/10.1186/1752-0509-3-22
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author Wu, Fan
Beard, Daniel A
author_facet Wu, Fan
Beard, Daniel A
author_sort Wu, Fan
collection PubMed
description BACKGROUND: The heart is capable of maintaining contractile function despite a transient decrease in blood flow and increase in cardiac ATP demand during systole. This study analyzes a previously developed model of cardiac energetics and oxygen transport to understand the roles of the creatine kinase system and myoglobin in maintaining the ATP hydrolysis potential during beat-to-beat transient changes in blood flow and ATP hydrolysis rate. RESULTS: The theoretical investigation demonstrates that elimination of myoglobin only slightly increases the predicted range of oscillation of cardiac oxygenation level during beat-to-beat transients in blood flow and ATP utilization. In silico elimination of myoglobin has almost no impact on the cytoplasmic ATP hydrolysis potential (ΔG(ATPase)). In contrast, disabling the creatine kinase system results in considerable oscillations of cytoplasmic ADP and ATP levels and seriously deteriorates the stability of ΔG(ATPase )in the beating heart. CONCLUSION: The CK system stabilizes ΔG(ATPase )by both buffering ATP and ADP concentrations and enhancing the feedback signal of inorganic phosphate in regulating mitochondrial oxidative phosphorylation.
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spelling pubmed-26674762009-04-10 Roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart Wu, Fan Beard, Daniel A BMC Syst Biol Research Article BACKGROUND: The heart is capable of maintaining contractile function despite a transient decrease in blood flow and increase in cardiac ATP demand during systole. This study analyzes a previously developed model of cardiac energetics and oxygen transport to understand the roles of the creatine kinase system and myoglobin in maintaining the ATP hydrolysis potential during beat-to-beat transient changes in blood flow and ATP hydrolysis rate. RESULTS: The theoretical investigation demonstrates that elimination of myoglobin only slightly increases the predicted range of oscillation of cardiac oxygenation level during beat-to-beat transients in blood flow and ATP utilization. In silico elimination of myoglobin has almost no impact on the cytoplasmic ATP hydrolysis potential (ΔG(ATPase)). In contrast, disabling the creatine kinase system results in considerable oscillations of cytoplasmic ADP and ATP levels and seriously deteriorates the stability of ΔG(ATPase )in the beating heart. CONCLUSION: The CK system stabilizes ΔG(ATPase )by both buffering ATP and ADP concentrations and enhancing the feedback signal of inorganic phosphate in regulating mitochondrial oxidative phosphorylation. BioMed Central 2009-02-19 /pmc/articles/PMC2667476/ /pubmed/19228404 http://dx.doi.org/10.1186/1752-0509-3-22 Text en Copyright © 2009 Wu and Beard; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wu, Fan
Beard, Daniel A
Roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart
title Roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart
title_full Roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart
title_fullStr Roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart
title_full_unstemmed Roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart
title_short Roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart
title_sort roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667476/
https://www.ncbi.nlm.nih.gov/pubmed/19228404
http://dx.doi.org/10.1186/1752-0509-3-22
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