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False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases
Fluorodeoxyglucose (FDG)-positron emission tomography (PET) is being used more and more to differentiate benign from malignant focal lesions and it has been shown to be more efficacious than conventional chest computed tomography (CT). However, FDG is not a cancer-specific agent, and false positive...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Radiological Society
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667579/ https://www.ncbi.nlm.nih.gov/pubmed/16549957 http://dx.doi.org/10.3348/kjr.2006.7.1.57 |
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author | Chang, Jung Min Lee, Hyun Ju Goo, Jin Mo Lee, Ho-Young Lee, Jong Jin Chung, June-Key Im, Jung-Gi |
author_facet | Chang, Jung Min Lee, Hyun Ju Goo, Jin Mo Lee, Ho-Young Lee, Jong Jin Chung, June-Key Im, Jung-Gi |
author_sort | Chang, Jung Min |
collection | PubMed |
description | Fluorodeoxyglucose (FDG)-positron emission tomography (PET) is being used more and more to differentiate benign from malignant focal lesions and it has been shown to be more efficacious than conventional chest computed tomography (CT). However, FDG is not a cancer-specific agent, and false positive findings in benign diseases have been reported. Infectious diseases (mycobacterial, fungal, bacterial infection), sarcoidosis, radiation pneumonitis and post-operative surgical conditions have shown intense uptake on PET scan. On the other hand, tumors with low glycolytic activity such as adenomas, bronchioloalveolar carcinomas, carcinoid tumors, low grade lymphomas and small sized tumors have revealed false negative findings on PET scan. Furthermore, in diseases located near the physiologic uptake sites (heart, bladder, kidney, and liver), FDG-PET should be complemented with other imaging modalities to confirm results and to minimize false negative findings. Familiarity with these false positive and negative findings will help radiologists interpret PET scans more accurately and also will help to determine the significance of the findings. In this review, we illustrate false positive and negative findings of PET scan in a variety of diseases. |
format | Text |
id | pubmed-2667579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | The Korean Radiological Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-26675792009-04-22 False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases Chang, Jung Min Lee, Hyun Ju Goo, Jin Mo Lee, Ho-Young Lee, Jong Jin Chung, June-Key Im, Jung-Gi Korean J Radiol Pictorial Essay Fluorodeoxyglucose (FDG)-positron emission tomography (PET) is being used more and more to differentiate benign from malignant focal lesions and it has been shown to be more efficacious than conventional chest computed tomography (CT). However, FDG is not a cancer-specific agent, and false positive findings in benign diseases have been reported. Infectious diseases (mycobacterial, fungal, bacterial infection), sarcoidosis, radiation pneumonitis and post-operative surgical conditions have shown intense uptake on PET scan. On the other hand, tumors with low glycolytic activity such as adenomas, bronchioloalveolar carcinomas, carcinoid tumors, low grade lymphomas and small sized tumors have revealed false negative findings on PET scan. Furthermore, in diseases located near the physiologic uptake sites (heart, bladder, kidney, and liver), FDG-PET should be complemented with other imaging modalities to confirm results and to minimize false negative findings. Familiarity with these false positive and negative findings will help radiologists interpret PET scans more accurately and also will help to determine the significance of the findings. In this review, we illustrate false positive and negative findings of PET scan in a variety of diseases. The Korean Radiological Society 2006 2006-03-31 /pmc/articles/PMC2667579/ /pubmed/16549957 http://dx.doi.org/10.3348/kjr.2006.7.1.57 Text en Copyright © 2006 The Korean Radiological Society http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Pictorial Essay Chang, Jung Min Lee, Hyun Ju Goo, Jin Mo Lee, Ho-Young Lee, Jong Jin Chung, June-Key Im, Jung-Gi False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases |
title | False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases |
title_full | False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases |
title_fullStr | False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases |
title_full_unstemmed | False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases |
title_short | False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases |
title_sort | false positive and false negative fdg-pet scans in various thoracic diseases |
topic | Pictorial Essay |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667579/ https://www.ncbi.nlm.nih.gov/pubmed/16549957 http://dx.doi.org/10.3348/kjr.2006.7.1.57 |
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