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A Mathematical Model for the Detection Mechanism of DNA Double-Strand Breaks Depending on Autophosphorylation of ATM

BACKGROUND: After IR stress, DNA double-strand breaks (DSBs) occur and repair proteins (RPs) bind to them, generating DSB-RP complexes (DSBCs), which results in repaired DSBs (RDSBs). In recent experimental studies, it is suggested that the ATM proteins detect these DNA lesions depending on the auto...

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Detalles Bibliográficos
Autores principales:	Mouri, Kazunari, Nacher, Jose C., Akutsu, Tatsuya
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667630/ https://www.ncbi.nlm.nih.gov/pubmed/19365581 http://dx.doi.org/10.1371/journal.pone.0005131

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