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The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion
Although many proteins can misfold into a self-seeding amyloid-like conformation1, only six are known to be infectious, i.e. prions; [PSI(+)], [PIN(+)], [URE3], [SWI(+)] and [HET-s] cause distinct heritable physiological changes in fungi2–4, while PrP(Sc) causes infectious encephalopathies in mammal...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667906/ https://www.ncbi.nlm.nih.gov/pubmed/19219034 http://dx.doi.org/10.1038/ncb1843 |