Update in Antiepidermal Growth Factor Receptor Therapy in the Management of Metastatic Colorectal Cancer

The approval of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies in the treatment of metastatic colorectal cancer (CRC) has expanded the armamentarium against this disease. This paper will review the historical progress and recent clinical developments of anti-EGFR therapies in the...

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Detalles Bibliográficos
Autores principales: Loong, Herbert H., Ma, Brigette B., Chan, Anthony T. C.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667934/
https://www.ncbi.nlm.nih.gov/pubmed/19365583
http://dx.doi.org/10.1155/2009/967920
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author Loong, Herbert H.
Ma, Brigette B.
Chan, Anthony T. C.
author_facet Loong, Herbert H.
Ma, Brigette B.
Chan, Anthony T. C.
author_sort Loong, Herbert H.
collection PubMed
description The approval of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies in the treatment of metastatic colorectal cancer (CRC) has expanded the armamentarium against this disease. This paper will review the historical progress and recent clinical developments of anti-EGFR therapies in the treatment of metastatic CRC. Novel strategies of targeting the EGFR pathway to improve efficacy as well as ongoing research in identifying specific molecular predictors of response will be discussed.
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spelling pubmed-26679342009-04-13 Update in Antiepidermal Growth Factor Receptor Therapy in the Management of Metastatic Colorectal Cancer Loong, Herbert H. Ma, Brigette B. Chan, Anthony T. C. J Oncol Review Article The approval of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies in the treatment of metastatic colorectal cancer (CRC) has expanded the armamentarium against this disease. This paper will review the historical progress and recent clinical developments of anti-EGFR therapies in the treatment of metastatic CRC. Novel strategies of targeting the EGFR pathway to improve efficacy as well as ongoing research in identifying specific molecular predictors of response will be discussed. Hindawi Publishing Corporation 2009 2009-04-09 /pmc/articles/PMC2667934/ /pubmed/19365583 http://dx.doi.org/10.1155/2009/967920 Text en Copyright © 2009 Herbert H. Loong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Loong, Herbert H.
Ma, Brigette B.
Chan, Anthony T. C.
Update in Antiepidermal Growth Factor Receptor Therapy in the Management of Metastatic Colorectal Cancer
title Update in Antiepidermal Growth Factor Receptor Therapy in the Management of Metastatic Colorectal Cancer
title_full Update in Antiepidermal Growth Factor Receptor Therapy in the Management of Metastatic Colorectal Cancer
title_fullStr Update in Antiepidermal Growth Factor Receptor Therapy in the Management of Metastatic Colorectal Cancer
title_full_unstemmed Update in Antiepidermal Growth Factor Receptor Therapy in the Management of Metastatic Colorectal Cancer
title_short Update in Antiepidermal Growth Factor Receptor Therapy in the Management of Metastatic Colorectal Cancer
title_sort update in antiepidermal growth factor receptor therapy in the management of metastatic colorectal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667934/
https://www.ncbi.nlm.nih.gov/pubmed/19365583
http://dx.doi.org/10.1155/2009/967920
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AT mabrigetteb updateinantiepidermalgrowthfactorreceptortherapyinthemanagementofmetastaticcolorectalcancer
AT chananthonytc updateinantiepidermalgrowthfactorreceptortherapyinthemanagementofmetastaticcolorectalcancer

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