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Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach

Endometriosis, a chronic disease characterized by endometrial tissue located outside the uterine cavity, affects one fourth of young women and is associated with chronic pelvic pain and infertility. However, an in-depth understanding of the pathophysiology and effective treatment strategies of endom...

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Autores principales: Tariverdian, Nadja, Theoharides, Theoharis C., Siedentopf, Friederike, Gutiérrez, Gabriela, Jeschke, Udo, Rabinovich, Gabriel A., Blois, Sandra M., Arck, Petra C.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668599/
https://www.ncbi.nlm.nih.gov/pubmed/17621704
http://dx.doi.org/10.1007/s00281-007-0077-0
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author Tariverdian, Nadja
Theoharides, Theoharis C.
Siedentopf, Friederike
Gutiérrez, Gabriela
Jeschke, Udo
Rabinovich, Gabriel A.
Blois, Sandra M.
Arck, Petra C.
author_facet Tariverdian, Nadja
Theoharides, Theoharis C.
Siedentopf, Friederike
Gutiérrez, Gabriela
Jeschke, Udo
Rabinovich, Gabriel A.
Blois, Sandra M.
Arck, Petra C.
author_sort Tariverdian, Nadja
collection PubMed
description Endometriosis, a chronic disease characterized by endometrial tissue located outside the uterine cavity, affects one fourth of young women and is associated with chronic pelvic pain and infertility. However, an in-depth understanding of the pathophysiology and effective treatment strategies of endometriosis is still largely elusive. Inadequate immune and neuroendocrine responses are significantly involved in the pathophysiology of endometriosis, and key findings are summarized in the present review. We discuss here the role of different immune mechanisms particularly adhesion molecules, protein–glycan interactions, and pro-angiogenic mediators in the development and progression of the disease. Finally, we introduce the concept of endometrial dissemination as result of a neuroendocrine-immune disequilibrium in response to high levels of perceived stress caused by cardinal clinical symptoms of endometriosis.
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spelling pubmed-26685992009-04-20 Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach Tariverdian, Nadja Theoharides, Theoharis C. Siedentopf, Friederike Gutiérrez, Gabriela Jeschke, Udo Rabinovich, Gabriel A. Blois, Sandra M. Arck, Petra C. Semin Immunopathol Review Endometriosis, a chronic disease characterized by endometrial tissue located outside the uterine cavity, affects one fourth of young women and is associated with chronic pelvic pain and infertility. However, an in-depth understanding of the pathophysiology and effective treatment strategies of endometriosis is still largely elusive. Inadequate immune and neuroendocrine responses are significantly involved in the pathophysiology of endometriosis, and key findings are summarized in the present review. We discuss here the role of different immune mechanisms particularly adhesion molecules, protein–glycan interactions, and pro-angiogenic mediators in the development and progression of the disease. Finally, we introduce the concept of endometrial dissemination as result of a neuroendocrine-immune disequilibrium in response to high levels of perceived stress caused by cardinal clinical symptoms of endometriosis. Springer-Verlag 2007-05-15 2007-06 /pmc/articles/PMC2668599/ /pubmed/17621704 http://dx.doi.org/10.1007/s00281-007-0077-0 Text en © Springer-Verlag 2007
spellingShingle Review
Tariverdian, Nadja
Theoharides, Theoharis C.
Siedentopf, Friederike
Gutiérrez, Gabriela
Jeschke, Udo
Rabinovich, Gabriel A.
Blois, Sandra M.
Arck, Petra C.
Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach
title Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach
title_full Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach
title_fullStr Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach
title_full_unstemmed Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach
title_short Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach
title_sort neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668599/
https://www.ncbi.nlm.nih.gov/pubmed/17621704
http://dx.doi.org/10.1007/s00281-007-0077-0
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