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Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach
Endometriosis, a chronic disease characterized by endometrial tissue located outside the uterine cavity, affects one fourth of young women and is associated with chronic pelvic pain and infertility. However, an in-depth understanding of the pathophysiology and effective treatment strategies of endom...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668599/ https://www.ncbi.nlm.nih.gov/pubmed/17621704 http://dx.doi.org/10.1007/s00281-007-0077-0 |
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author | Tariverdian, Nadja Theoharides, Theoharis C. Siedentopf, Friederike Gutiérrez, Gabriela Jeschke, Udo Rabinovich, Gabriel A. Blois, Sandra M. Arck, Petra C. |
author_facet | Tariverdian, Nadja Theoharides, Theoharis C. Siedentopf, Friederike Gutiérrez, Gabriela Jeschke, Udo Rabinovich, Gabriel A. Blois, Sandra M. Arck, Petra C. |
author_sort | Tariverdian, Nadja |
collection | PubMed |
description | Endometriosis, a chronic disease characterized by endometrial tissue located outside the uterine cavity, affects one fourth of young women and is associated with chronic pelvic pain and infertility. However, an in-depth understanding of the pathophysiology and effective treatment strategies of endometriosis is still largely elusive. Inadequate immune and neuroendocrine responses are significantly involved in the pathophysiology of endometriosis, and key findings are summarized in the present review. We discuss here the role of different immune mechanisms particularly adhesion molecules, protein–glycan interactions, and pro-angiogenic mediators in the development and progression of the disease. Finally, we introduce the concept of endometrial dissemination as result of a neuroendocrine-immune disequilibrium in response to high levels of perceived stress caused by cardinal clinical symptoms of endometriosis. |
format | Text |
id | pubmed-2668599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-26685992009-04-20 Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach Tariverdian, Nadja Theoharides, Theoharis C. Siedentopf, Friederike Gutiérrez, Gabriela Jeschke, Udo Rabinovich, Gabriel A. Blois, Sandra M. Arck, Petra C. Semin Immunopathol Review Endometriosis, a chronic disease characterized by endometrial tissue located outside the uterine cavity, affects one fourth of young women and is associated with chronic pelvic pain and infertility. However, an in-depth understanding of the pathophysiology and effective treatment strategies of endometriosis is still largely elusive. Inadequate immune and neuroendocrine responses are significantly involved in the pathophysiology of endometriosis, and key findings are summarized in the present review. We discuss here the role of different immune mechanisms particularly adhesion molecules, protein–glycan interactions, and pro-angiogenic mediators in the development and progression of the disease. Finally, we introduce the concept of endometrial dissemination as result of a neuroendocrine-immune disequilibrium in response to high levels of perceived stress caused by cardinal clinical symptoms of endometriosis. Springer-Verlag 2007-05-15 2007-06 /pmc/articles/PMC2668599/ /pubmed/17621704 http://dx.doi.org/10.1007/s00281-007-0077-0 Text en © Springer-Verlag 2007 |
spellingShingle | Review Tariverdian, Nadja Theoharides, Theoharis C. Siedentopf, Friederike Gutiérrez, Gabriela Jeschke, Udo Rabinovich, Gabriel A. Blois, Sandra M. Arck, Petra C. Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach |
title | Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach |
title_full | Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach |
title_fullStr | Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach |
title_full_unstemmed | Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach |
title_short | Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach |
title_sort | neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668599/ https://www.ncbi.nlm.nih.gov/pubmed/17621704 http://dx.doi.org/10.1007/s00281-007-0077-0 |
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