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Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

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In a randomized, placebo-controlled trial in Ghana, 67 onchocerciasis patients received 200-mg/day doxycycline for 4–6 weeks, followed by ivermectin (IVM) after 6 months. After 6–27 months, efficacy was evaluated by onchocercoma histology, PCR and microfilariae determination. Administration of doxyc...

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Detalles Bibliográficos
Autores principales:	Hoerauf, Achim, Specht, Sabine, Büttner, Marcelle, Pfarr, Kenneth, Mand, Sabine, Fimmers, Rolf, Marfo-Debrekyei, Yeboah, Konadu, Peter, Debrah, Alexander Yaw, Bandi, Claudio, Brattig, Norbert, Albers, Anna, Larbi, John, Batsa, Linda, Adjei, Ohene, Büttner, Dietrich W.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2007
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668626/ https://www.ncbi.nlm.nih.gov/pubmed/17999080 http://dx.doi.org/10.1007/s00430-007-0062-1

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