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The in- or exclusion of non-breast cancer related death and contralateral breast cancer significantly affects estimated outcome probability in early breast cancer

A wide variation of definitions of recurrent disease and survival are used in the analyses of outcome of patients with early breast cancer. Explicit definitions with details both on endpoints and censoring are provided in less than half of published studies. We evaluated the effects of various defin...

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Detalles Bibliográficos
Autores principales: Nout, R. A., Fiets, W. E., Struikmans, H., Rosendaal, F. R., Putter, H., Nortier, J. W. R.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668629/
https://www.ncbi.nlm.nih.gov/pubmed/17661169
http://dx.doi.org/10.1007/s10549-007-9681-x
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author Nout, R. A.
Fiets, W. E.
Struikmans, H.
Rosendaal, F. R.
Putter, H.
Nortier, J. W. R.
author_facet Nout, R. A.
Fiets, W. E.
Struikmans, H.
Rosendaal, F. R.
Putter, H.
Nortier, J. W. R.
author_sort Nout, R. A.
collection PubMed
description A wide variation of definitions of recurrent disease and survival are used in the analyses of outcome of patients with early breast cancer. Explicit definitions with details both on endpoints and censoring are provided in less than half of published studies. We evaluated the effects of various definitions of survival and recurrent disease on estimated outcome in a prospectively determined cohort of 463 patients with primary breast cancer. Outcome estimates were determined both by the Kaplan–Meier and a competing risk method. In- or exclusion of contralateral breast cancer or non-disease related death in the definition of recurrent disease or survival significantly affects estimated outcome probability. The magnitude of this finding was dependent on patient-, tumour-, and treatment characteristics. Knowledge of the contribution of non-disease related death or contralateral breast cancer to estimated recurrent disease rate and overall death rate is indispensable for a correct interpretation and comparison of outcome analyses.
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spelling pubmed-26686292009-04-20 The in- or exclusion of non-breast cancer related death and contralateral breast cancer significantly affects estimated outcome probability in early breast cancer Nout, R. A. Fiets, W. E. Struikmans, H. Rosendaal, F. R. Putter, H. Nortier, J. W. R. Breast Cancer Res Treat Epidemiology A wide variation of definitions of recurrent disease and survival are used in the analyses of outcome of patients with early breast cancer. Explicit definitions with details both on endpoints and censoring are provided in less than half of published studies. We evaluated the effects of various definitions of survival and recurrent disease on estimated outcome in a prospectively determined cohort of 463 patients with primary breast cancer. Outcome estimates were determined both by the Kaplan–Meier and a competing risk method. In- or exclusion of contralateral breast cancer or non-disease related death in the definition of recurrent disease or survival significantly affects estimated outcome probability. The magnitude of this finding was dependent on patient-, tumour-, and treatment characteristics. Knowledge of the contribution of non-disease related death or contralateral breast cancer to estimated recurrent disease rate and overall death rate is indispensable for a correct interpretation and comparison of outcome analyses. Springer US 2007-07-28 2008-06 /pmc/articles/PMC2668629/ /pubmed/17661169 http://dx.doi.org/10.1007/s10549-007-9681-x Text en © Springer Science+Business Media, LLC 2007
spellingShingle Epidemiology
Nout, R. A.
Fiets, W. E.
Struikmans, H.
Rosendaal, F. R.
Putter, H.
Nortier, J. W. R.
The in- or exclusion of non-breast cancer related death and contralateral breast cancer significantly affects estimated outcome probability in early breast cancer
title The in- or exclusion of non-breast cancer related death and contralateral breast cancer significantly affects estimated outcome probability in early breast cancer
title_full The in- or exclusion of non-breast cancer related death and contralateral breast cancer significantly affects estimated outcome probability in early breast cancer
title_fullStr The in- or exclusion of non-breast cancer related death and contralateral breast cancer significantly affects estimated outcome probability in early breast cancer
title_full_unstemmed The in- or exclusion of non-breast cancer related death and contralateral breast cancer significantly affects estimated outcome probability in early breast cancer
title_short The in- or exclusion of non-breast cancer related death and contralateral breast cancer significantly affects estimated outcome probability in early breast cancer
title_sort in- or exclusion of non-breast cancer related death and contralateral breast cancer significantly affects estimated outcome probability in early breast cancer
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668629/
https://www.ncbi.nlm.nih.gov/pubmed/17661169
http://dx.doi.org/10.1007/s10549-007-9681-x
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