Cargando…

Genetic Variance in the Adiponutrin Gene Family and Childhood Obesity

AIM: The adiponutrin gene family consists of five genes (PNPLA1-5) coding for proteins with both lipolytic and lipogenic properties. PNPLA3 has previously been associated with adult obesity. Here we investigated the possible association between genetic variants in these genes and childhood and adole...

Descripción completa

Detalles Bibliográficos
Autores principales: Johansson, Lovisa E., Johansson, Lina M., Danielsson, Pernilla, Norgren, Svante, Johansson, Stina, Marcus, Claude, Ridderstråle, Martin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669125/
https://www.ncbi.nlm.nih.gov/pubmed/19390624
http://dx.doi.org/10.1371/journal.pone.0005327
_version_ 1782166234506199040
author Johansson, Lovisa E.
Johansson, Lina M.
Danielsson, Pernilla
Norgren, Svante
Johansson, Stina
Marcus, Claude
Ridderstråle, Martin
author_facet Johansson, Lovisa E.
Johansson, Lina M.
Danielsson, Pernilla
Norgren, Svante
Johansson, Stina
Marcus, Claude
Ridderstråle, Martin
author_sort Johansson, Lovisa E.
collection PubMed
description AIM: The adiponutrin gene family consists of five genes (PNPLA1-5) coding for proteins with both lipolytic and lipogenic properties. PNPLA3 has previously been associated with adult obesity. Here we investigated the possible association between genetic variants in these genes and childhood and adolescent obesity. METHODS/RESULTS: Polymorphisms in the five genes of the adiponutrin gene family were selected and genotyped using the Sequenom platform in a childhood and adolescent obesity case-control study. Six variants in PNPLA1 showed association with obesity (rs9380559, rs12212459, rs1467912, rs4713951, rs10947600, and rs12199580, p<0.05 after adjustment for age and gender). Three variants in PNPLA3 showed association with obesity before, but not after, adjustment for age and gender (rs139051, rs12483959, and rs2072907, p>0.05). When analyzing these SNPs in relation to phenotypes, two SNPs in the PNPLA3 gene showed association with insulin sensitivity (rs12483959: β = −0.053, p = 0.016, and rs2072907: β = −0.049, p = 0.024). No associations were seen for PNPLA2, PNPLA4, and PNPLA5. CONCLUSIONS: Genetic variation in the adiponutrin gene family does not seem to contribute strongly to obesity in children and adolescents. PNPLA1 exhibited a modest effect on obesity and PNPLA3 on insulin sensitivity. These data, however, require confirmation in other cohorts and ethnic groups.
format Text
id pubmed-2669125
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-26691252009-04-24 Genetic Variance in the Adiponutrin Gene Family and Childhood Obesity Johansson, Lovisa E. Johansson, Lina M. Danielsson, Pernilla Norgren, Svante Johansson, Stina Marcus, Claude Ridderstråle, Martin PLoS One Research Article AIM: The adiponutrin gene family consists of five genes (PNPLA1-5) coding for proteins with both lipolytic and lipogenic properties. PNPLA3 has previously been associated with adult obesity. Here we investigated the possible association between genetic variants in these genes and childhood and adolescent obesity. METHODS/RESULTS: Polymorphisms in the five genes of the adiponutrin gene family were selected and genotyped using the Sequenom platform in a childhood and adolescent obesity case-control study. Six variants in PNPLA1 showed association with obesity (rs9380559, rs12212459, rs1467912, rs4713951, rs10947600, and rs12199580, p<0.05 after adjustment for age and gender). Three variants in PNPLA3 showed association with obesity before, but not after, adjustment for age and gender (rs139051, rs12483959, and rs2072907, p>0.05). When analyzing these SNPs in relation to phenotypes, two SNPs in the PNPLA3 gene showed association with insulin sensitivity (rs12483959: β = −0.053, p = 0.016, and rs2072907: β = −0.049, p = 0.024). No associations were seen for PNPLA2, PNPLA4, and PNPLA5. CONCLUSIONS: Genetic variation in the adiponutrin gene family does not seem to contribute strongly to obesity in children and adolescents. PNPLA1 exhibited a modest effect on obesity and PNPLA3 on insulin sensitivity. These data, however, require confirmation in other cohorts and ethnic groups. Public Library of Science 2009-04-24 /pmc/articles/PMC2669125/ /pubmed/19390624 http://dx.doi.org/10.1371/journal.pone.0005327 Text en Johansson et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Johansson, Lovisa E.
Johansson, Lina M.
Danielsson, Pernilla
Norgren, Svante
Johansson, Stina
Marcus, Claude
Ridderstråle, Martin
Genetic Variance in the Adiponutrin Gene Family and Childhood Obesity
title Genetic Variance in the Adiponutrin Gene Family and Childhood Obesity
title_full Genetic Variance in the Adiponutrin Gene Family and Childhood Obesity
title_fullStr Genetic Variance in the Adiponutrin Gene Family and Childhood Obesity
title_full_unstemmed Genetic Variance in the Adiponutrin Gene Family and Childhood Obesity
title_short Genetic Variance in the Adiponutrin Gene Family and Childhood Obesity
title_sort genetic variance in the adiponutrin gene family and childhood obesity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669125/
https://www.ncbi.nlm.nih.gov/pubmed/19390624
http://dx.doi.org/10.1371/journal.pone.0005327
work_keys_str_mv AT johanssonlovisae geneticvarianceintheadiponutringenefamilyandchildhoodobesity
AT johanssonlinam geneticvarianceintheadiponutringenefamilyandchildhoodobesity
AT danielssonpernilla geneticvarianceintheadiponutringenefamilyandchildhoodobesity
AT norgrensvante geneticvarianceintheadiponutringenefamilyandchildhoodobesity
AT johanssonstina geneticvarianceintheadiponutringenefamilyandchildhoodobesity
AT marcusclaude geneticvarianceintheadiponutringenefamilyandchildhoodobesity
AT ridderstralemartin geneticvarianceintheadiponutringenefamilyandchildhoodobesity