Dengue Virus Serotype 2 from a Sylvatic Lineage Isolated from a Patient with Dengue Hemorrhagic Fever

Dengue viruses circulate in both human and sylvatic cycles. Although dengue viruses (DENV) infecting humans can cause major epidemics and severe disease, relatively little is known about the epidemiology and etiology of sylvatic dengue viruses. A 20-year-old male developed dengue hemorrhagic fever (...

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Detalles Bibliográficos
Autores principales: Cardosa, Jane, Ooi, Mong How, Tio, Phaik Hooi, Perera, David, Holmes, Edward C., Bibi, Khatijar, Abdul Manap, Zahara
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669127/
https://www.ncbi.nlm.nih.gov/pubmed/19399166
http://dx.doi.org/10.1371/journal.pntd.0000423
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author Cardosa, Jane
Ooi, Mong How
Tio, Phaik Hooi
Perera, David
Holmes, Edward C.
Bibi, Khatijar
Abdul Manap, Zahara
author_facet Cardosa, Jane
Ooi, Mong How
Tio, Phaik Hooi
Perera, David
Holmes, Edward C.
Bibi, Khatijar
Abdul Manap, Zahara
author_sort Cardosa, Jane
collection PubMed
description Dengue viruses circulate in both human and sylvatic cycles. Although dengue viruses (DENV) infecting humans can cause major epidemics and severe disease, relatively little is known about the epidemiology and etiology of sylvatic dengue viruses. A 20-year-old male developed dengue hemorrhagic fever (DHF) with thrombocytopenia (12,000/ul) and a raised hematocrit (29.5% above baseline) in January 2008 in Malaysia. Dengue virus serotype 2 was isolated from his blood on day 4 of fever. A phylogenetic analysis of the complete genome sequence revealed that this virus was a member of a sylvatic lineage of DENV-2 and most closely related to a virus isolated from a sentinel monkey in Malaysia in 1970. This is the first identification of a sylvatic DENV circulating in Asia since 1975.
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spelling pubmed-26691272009-04-28 Dengue Virus Serotype 2 from a Sylvatic Lineage Isolated from a Patient with Dengue Hemorrhagic Fever Cardosa, Jane Ooi, Mong How Tio, Phaik Hooi Perera, David Holmes, Edward C. Bibi, Khatijar Abdul Manap, Zahara PLoS Negl Trop Dis Research Article Dengue viruses circulate in both human and sylvatic cycles. Although dengue viruses (DENV) infecting humans can cause major epidemics and severe disease, relatively little is known about the epidemiology and etiology of sylvatic dengue viruses. A 20-year-old male developed dengue hemorrhagic fever (DHF) with thrombocytopenia (12,000/ul) and a raised hematocrit (29.5% above baseline) in January 2008 in Malaysia. Dengue virus serotype 2 was isolated from his blood on day 4 of fever. A phylogenetic analysis of the complete genome sequence revealed that this virus was a member of a sylvatic lineage of DENV-2 and most closely related to a virus isolated from a sentinel monkey in Malaysia in 1970. This is the first identification of a sylvatic DENV circulating in Asia since 1975. Public Library of Science 2009-04-28 /pmc/articles/PMC2669127/ /pubmed/19399166 http://dx.doi.org/10.1371/journal.pntd.0000423 Text en Cardosa et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Cardosa, Jane
Ooi, Mong How
Tio, Phaik Hooi
Perera, David
Holmes, Edward C.
Bibi, Khatijar
Abdul Manap, Zahara
Dengue Virus Serotype 2 from a Sylvatic Lineage Isolated from a Patient with Dengue Hemorrhagic Fever
title Dengue Virus Serotype 2 from a Sylvatic Lineage Isolated from a Patient with Dengue Hemorrhagic Fever
title_full Dengue Virus Serotype 2 from a Sylvatic Lineage Isolated from a Patient with Dengue Hemorrhagic Fever
title_fullStr Dengue Virus Serotype 2 from a Sylvatic Lineage Isolated from a Patient with Dengue Hemorrhagic Fever
title_full_unstemmed Dengue Virus Serotype 2 from a Sylvatic Lineage Isolated from a Patient with Dengue Hemorrhagic Fever
title_short Dengue Virus Serotype 2 from a Sylvatic Lineage Isolated from a Patient with Dengue Hemorrhagic Fever
title_sort dengue virus serotype 2 from a sylvatic lineage isolated from a patient with dengue hemorrhagic fever
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669127/
https://www.ncbi.nlm.nih.gov/pubmed/19399166
http://dx.doi.org/10.1371/journal.pntd.0000423
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