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Metnase Mediates Resistance to Topoisomerase II Inhibitors in Breast Cancer Cells

DNA replication produces tangled, or catenated, chromatids, that must be decatenated prior to mitosis or catastrophic genomic damage will occur. Topoisomerase IIα (Topo IIα) is the primary decatenating enzyme. Cells monitor catenation status and activate decatenation checkpoints when decatenation is...

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Detalles Bibliográficos
Autores principales:	Wray, Justin, Williamson, Elizabeth A., Royce, Melanie, Shaheen, Montaser, Beck, Brian D., Lee, Suk-Hee, Nickoloff, Jac A., Hromas, Robert
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669129/ https://www.ncbi.nlm.nih.gov/pubmed/19390626 http://dx.doi.org/10.1371/journal.pone.0005323

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