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Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates
The two main routes that cells use for degrading intracellular proteins are the ubiquitin-proteasome and autophagy-lysosome pathways, which have been thought to have largely distinct clients. Here, we show that autophagy inhibition increases levels of proteasome substrates. This is largely due to p6...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669153/ https://www.ncbi.nlm.nih.gov/pubmed/19250912 http://dx.doi.org/10.1016/j.molcel.2009.01.021 |