The Spliceosomal Phosphopeptide P140 Controls the Lupus Disease by Interacting with the HSC70 Protein and via a Mechanism Mediated by γδ T Cells

The phosphopeptide P140 issued from the spliceosomal U1-70K snRNP protein is recognized by lupus CD4(+) T cells, transiently abolishes T cell reactivity to other spliceosomal peptides in P140-treated MRL/lpr mice, and ameliorates their clinical features. P140 modulates lupus patients' T cell re...

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Detalles Bibliográficos
Autores principales: Page, Nicolas, Schall, Nicolas, Strub, Jean-Marc, Quinternet, Marc, Chaloin, Olivier, Décossas, Marion, Cung, Manh Thong, Van Dorsselaer, Alain, Briand, Jean-Paul, Muller, Sylviane
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669294/
https://www.ncbi.nlm.nih.gov/pubmed/19390596
http://dx.doi.org/10.1371/journal.pone.0005273

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