An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene

BACKGROUND: Multiple sclerosis (MS) is a complex trait in which genes in the MHC class II region exert the single strongest effect on genetic susceptibility. The principal MHC class II haplotype that increases MS risk in individuals of Northern European descent are those that bear HLA-DRB1*15. Howev...

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Detalles Bibliográficos
Autores principales: Ramagopalan, Sreeram V, McMahon, Roisin, Dyment, David A, Sadovnick, A Dessa, Ebers, George C, Wittkowski, Knut M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669470/
https://www.ncbi.nlm.nih.gov/pubmed/19193207
http://dx.doi.org/10.1186/1471-2350-10-10

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