Pro370Leu mutant myocilin disturbs the endoplasm reticulum stress response and mitochondrial membrane potential in human trabecular meshwork cells

PURPOSE: To investigate the impact of Pro370Leu mutant myocilin on endoplasmic reticulum (ER) stress response and mitochondria function in human trabecular meshwork (HTM) cells. METHODS: HTM cells were transfected with wild-type Pro370Leu mutant myocilin or pcDNA3.1 (+) expression plasmids. The effe...

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Detalles Bibliográficos
Autores principales: Wang, Lina, Zhuo, Yehong, Liu, Bingqian, Huang, Shengsong, Hou, Fei, Ge, Jian
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669509/
https://www.ncbi.nlm.nih.gov/pubmed/17515882

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