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Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids

Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o-H(2)BZA or p-H(2)BZA) of formulae [R(2)Sn(HL)(2)] (where H(2)L = o-H(2)BZA and R = Me- (1), n-Bu- (2)); [R(3)Sn(HL)] (where H(2)L = o-H(2)BZA and R = n-Bu- (3), Ph- (4) or H(2)L = p-H(2)BZA and R = n-Bu- (5), Ph- (6)) were synthesized by r...

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Autores principales: Abdellah, Mohamed A., Hadjikakou, Sotiris K., Hadjiliadis, Nick, Kubicki, Maciej, Bakas, Thomas, Kourkoumelis, Nikolaos, Simos, Yannis V., Karkabounas, Spyros, Barsan, Mirela M., Butler, Ian S.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669538/
https://www.ncbi.nlm.nih.gov/pubmed/19390627
http://dx.doi.org/10.1155/2009/542979
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author Abdellah, Mohamed A.
Hadjikakou, Sotiris K.
Hadjiliadis, Nick
Kubicki, Maciej
Bakas, Thomas
Kourkoumelis, Nikolaos
Simos, Yannis V.
Karkabounas, Spyros
Barsan, Mirela M.
Butler, Ian S.
author_facet Abdellah, Mohamed A.
Hadjikakou, Sotiris K.
Hadjiliadis, Nick
Kubicki, Maciej
Bakas, Thomas
Kourkoumelis, Nikolaos
Simos, Yannis V.
Karkabounas, Spyros
Barsan, Mirela M.
Butler, Ian S.
author_sort Abdellah, Mohamed A.
collection PubMed
description Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o-H(2)BZA or p-H(2)BZA) of formulae [R(2)Sn(HL)(2)] (where H(2)L = o-H(2)BZA and R = Me- (1), n-Bu- (2)); [R(3)Sn(HL)] (where H(2)L = o-H(2)BZA and R = n-Bu- (3), Ph- (4) or H(2)L = p-H(2)BZA and R = n-Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o-H(2)BZA or p-H(2)BZA) containing equimolar amounts of potassium hydroxide. The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mössbauer spectroscopy, (1)H, (119)Sn-NMR, UV/Vis spectroscopy, and Mass spectroscopy. The X-ray crystal structures of complexes 1 and 2 have also been determined. Finally, the influence of these complexes 1–6 upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically studied and the results showed that triorganotin(IV) complex 6 has the lowest IC(50) value. Also complexes 1–6 were studied for their in vitro cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, and the results showed that the complexes have high activity against these cell lines with triphenyltin((IV) complex 4 to be the most active one.
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spelling pubmed-26695382009-04-23 Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids Abdellah, Mohamed A. Hadjikakou, Sotiris K. Hadjiliadis, Nick Kubicki, Maciej Bakas, Thomas Kourkoumelis, Nikolaos Simos, Yannis V. Karkabounas, Spyros Barsan, Mirela M. Butler, Ian S. Bioinorg Chem Appl Research Article Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o-H(2)BZA or p-H(2)BZA) of formulae [R(2)Sn(HL)(2)] (where H(2)L = o-H(2)BZA and R = Me- (1), n-Bu- (2)); [R(3)Sn(HL)] (where H(2)L = o-H(2)BZA and R = n-Bu- (3), Ph- (4) or H(2)L = p-H(2)BZA and R = n-Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o-H(2)BZA or p-H(2)BZA) containing equimolar amounts of potassium hydroxide. The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mössbauer spectroscopy, (1)H, (119)Sn-NMR, UV/Vis spectroscopy, and Mass spectroscopy. The X-ray crystal structures of complexes 1 and 2 have also been determined. Finally, the influence of these complexes 1–6 upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically studied and the results showed that triorganotin(IV) complex 6 has the lowest IC(50) value. Also complexes 1–6 were studied for their in vitro cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, and the results showed that the complexes have high activity against these cell lines with triphenyltin((IV) complex 4 to be the most active one. Hindawi Publishing Corporation 2009 2009-04-15 /pmc/articles/PMC2669538/ /pubmed/19390627 http://dx.doi.org/10.1155/2009/542979 Text en Copyright © 2009 Mohamed A. Abdellah et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Abdellah, Mohamed A.
Hadjikakou, Sotiris K.
Hadjiliadis, Nick
Kubicki, Maciej
Bakas, Thomas
Kourkoumelis, Nikolaos
Simos, Yannis V.
Karkabounas, Spyros
Barsan, Mirela M.
Butler, Ian S.
Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids
title Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids
title_full Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids
title_fullStr Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids
title_full_unstemmed Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids
title_short Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids
title_sort synthesis, characterization, and biological studies of organotin(iv) derivatives with o- or p-hydroxybenzoic acids
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669538/
https://www.ncbi.nlm.nih.gov/pubmed/19390627
http://dx.doi.org/10.1155/2009/542979
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