Tobacco Xenobiotics Release Nitric Oxide

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Many xenobiotic compounds exert their actions through the release of free radicals and related oxidants [1,2], bringing about unwanted biological effects [3]. Indeed, oxidative events may play a significant role in tobacco toxicity from cigarette smoke. Here, we demonstrate the direct in vitro relea...

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Detalles Bibliográficos
Autores principales: Lam, EWN, Kelley, EE, Martin, SM, Buettner, GR
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669559/
http://dx.doi.org/10.1186/1617-9625-1-19
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author Lam, EWN
Kelley, EE
Martin, SM
Buettner, GR
author_facet Lam, EWN
Kelley, EE
Martin, SM
Buettner, GR
author_sort Lam, EWN
collection PubMed
description Many xenobiotic compounds exert their actions through the release of free radicals and related oxidants [1,2], bringing about unwanted biological effects [3]. Indeed, oxidative events may play a significant role in tobacco toxicity from cigarette smoke. Here, we demonstrate the direct in vitro release of the free radical nitric oxide ((•)NO) from extracts and components of smokeless tobacco, including nicotine, nitrosonornicotine (NNN) and 4-(methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in phosphate buffered saline and human saliva using electron spin resonance and chemiluminescence detection. Our findings suggest that tobacco xenobiotics represent as yet unrecognized sources of (•)NO in the body.
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spelling pubmed-26695592009-04-16 Tobacco Xenobiotics Release Nitric Oxide Lam, EWN Kelley, EE Martin, SM Buettner, GR Tob Induc Dis Research Many xenobiotic compounds exert their actions through the release of free radicals and related oxidants [1,2], bringing about unwanted biological effects [3]. Indeed, oxidative events may play a significant role in tobacco toxicity from cigarette smoke. Here, we demonstrate the direct in vitro release of the free radical nitric oxide ((•)NO) from extracts and components of smokeless tobacco, including nicotine, nitrosonornicotine (NNN) and 4-(methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in phosphate buffered saline and human saliva using electron spin resonance and chemiluminescence detection. Our findings suggest that tobacco xenobiotics represent as yet unrecognized sources of (•)NO in the body. BioMed Central 2003-09-15 /pmc/articles/PMC2669559/ http://dx.doi.org/10.1186/1617-9625-1-19 Text en Copyright © 2003 Lam et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Lam, EWN
Kelley, EE
Martin, SM
Buettner, GR
Tobacco Xenobiotics Release Nitric Oxide
title Tobacco Xenobiotics Release Nitric Oxide
title_full Tobacco Xenobiotics Release Nitric Oxide
title_fullStr Tobacco Xenobiotics Release Nitric Oxide
title_full_unstemmed Tobacco Xenobiotics Release Nitric Oxide
title_short Tobacco Xenobiotics Release Nitric Oxide
title_sort tobacco xenobiotics release nitric oxide
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669559/
http://dx.doi.org/10.1186/1617-9625-1-19
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AT kelleyee tobaccoxenobioticsreleasenitricoxide
AT martinsm tobaccoxenobioticsreleasenitricoxide
AT buettnergr tobaccoxenobioticsreleasenitricoxide

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