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The influence of tobacco smoking on adhesion molecule profiles

Sequential interactions between several adhesion molecules and their ligands regulate lymphocyte circulation and leukocyte recruitment to inflammatory foci. Adhesion molecules are, therefore, central and critical components of the immune and inflammatory system. We review the evidence that tobacco s...

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Detalles Bibliográficos
Autores principales: Scott, DA, Palmer, RM
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669563/
http://dx.doi.org/10.1186/1617-9625-1-3
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author Scott, DA
Palmer, RM
author_facet Scott, DA
Palmer, RM
author_sort Scott, DA
collection PubMed
description Sequential interactions between several adhesion molecules and their ligands regulate lymphocyte circulation and leukocyte recruitment to inflammatory foci. Adhesion molecules are, therefore, central and critical components of the immune and inflammatory system. We review the evidence that tobacco smoking dysregulates specific components of the adhesion cascade, which may be a common factor in several smoking-induced diseases. Smoking causes inappropriate leukocyte activation, leukocyte-endothelial adhesion, and neutrophil entrapment in the microvasculature, which may help initiate local tissue destruction. Appropriate inflammatory reactions may thus be compromised. In addition to smoke-induced alterations to membrane bound endothelial and leukocyte adhesion molecule expression, which may help explain the above phenomena, smoking has a profound influence on circulating adhesion molecule profiles, most notably sICAM-1 and specific sCD44 variants. Elevated concentrations of soluble adhesion molecules may simply reflect ongoing inflammatory processes. However, increasing evidence suggests that specific soluble adhesion molecules are immunomodulatory, and that alterations to soluble adhesion molecule profiles may represent a significant risk factor for several diverse diseases. This evidence is discussed herein.
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spelling pubmed-26695632009-04-16 The influence of tobacco smoking on adhesion molecule profiles Scott, DA Palmer, RM Tob Induc Dis Review Sequential interactions between several adhesion molecules and their ligands regulate lymphocyte circulation and leukocyte recruitment to inflammatory foci. Adhesion molecules are, therefore, central and critical components of the immune and inflammatory system. We review the evidence that tobacco smoking dysregulates specific components of the adhesion cascade, which may be a common factor in several smoking-induced diseases. Smoking causes inappropriate leukocyte activation, leukocyte-endothelial adhesion, and neutrophil entrapment in the microvasculature, which may help initiate local tissue destruction. Appropriate inflammatory reactions may thus be compromised. In addition to smoke-induced alterations to membrane bound endothelial and leukocyte adhesion molecule expression, which may help explain the above phenomena, smoking has a profound influence on circulating adhesion molecule profiles, most notably sICAM-1 and specific sCD44 variants. Elevated concentrations of soluble adhesion molecules may simply reflect ongoing inflammatory processes. However, increasing evidence suggests that specific soluble adhesion molecules are immunomodulatory, and that alterations to soluble adhesion molecule profiles may represent a significant risk factor for several diverse diseases. This evidence is discussed herein. BioMed Central 2002-01-15 /pmc/articles/PMC2669563/ http://dx.doi.org/10.1186/1617-9625-1-3 Text en Copyright © 2003 Scott and Palmer; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Scott, DA
Palmer, RM
The influence of tobacco smoking on adhesion molecule profiles
title The influence of tobacco smoking on adhesion molecule profiles
title_full The influence of tobacco smoking on adhesion molecule profiles
title_fullStr The influence of tobacco smoking on adhesion molecule profiles
title_full_unstemmed The influence of tobacco smoking on adhesion molecule profiles
title_short The influence of tobacco smoking on adhesion molecule profiles
title_sort influence of tobacco smoking on adhesion molecule profiles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669563/
http://dx.doi.org/10.1186/1617-9625-1-3
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