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Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin
We investigated the potential usefulness of vesnarinone, a novel cytokine inhibitor, for the treatment of lung fibrosis using a murine model of bleomycin (BLM)-induced pulmonary fibrosis. Mice were fed a control diet (n=42), or a diet containing low (n=42) or high (n=42) dose of vesnarinone. Dietary...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669598/ https://www.ncbi.nlm.nih.gov/pubmed/19381349 |
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author | Inage, Minoru Nakamura, Hidenori Saito, Hiroshi Abe, Shuichi Hino, Toshihiko Takabatake, Noriaki Terashita, Kyoko Ogura, Manabu Kato, Shuichi Hosokawa, Tetsumi Sata, Makoto Tomoike, Hitonobu |
author_facet | Inage, Minoru Nakamura, Hidenori Saito, Hiroshi Abe, Shuichi Hino, Toshihiko Takabatake, Noriaki Terashita, Kyoko Ogura, Manabu Kato, Shuichi Hosokawa, Tetsumi Sata, Makoto Tomoike, Hitonobu |
author_sort | Inage, Minoru |
collection | PubMed |
description | We investigated the potential usefulness of vesnarinone, a novel cytokine inhibitor, for the treatment of lung fibrosis using a murine model of bleomycin (BLM)-induced pulmonary fibrosis. Mice were fed a control diet (n=42), or a diet containing low (n=42) or high (n=42) dose of vesnarinone. Dietary intake of vesnarinone minimized the BLM toxicity as reflected by significant decreases in numbers of inflammatory cells, KC, and soluble TNF receptors in the bronchoalveolar lavage fluid. A quantitative evaluation of histology demonstrated significantly mild lung parenchymal lesions in BLM-treated mice fed with diet containing high dose of vesnarinone than in the control diet group. Consistent with the histopathology, hydroxyproline levels in lung tissue from BLM-treated mice fed with diet containing vesnarinone were significantly lower than that from mice fed with control diet. We concluded that vesnarinone inhibits BLM-induced pulmonary fibrosis, at least in part, by the inhibition of acute lung injuries in the early phase. |
format | Text |
id | pubmed-2669598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-26695982009-04-16 Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin Inage, Minoru Nakamura, Hidenori Saito, Hiroshi Abe, Shuichi Hino, Toshihiko Takabatake, Noriaki Terashita, Kyoko Ogura, Manabu Kato, Shuichi Hosokawa, Tetsumi Sata, Makoto Tomoike, Hitonobu Int J Biol Sci Research Paper We investigated the potential usefulness of vesnarinone, a novel cytokine inhibitor, for the treatment of lung fibrosis using a murine model of bleomycin (BLM)-induced pulmonary fibrosis. Mice were fed a control diet (n=42), or a diet containing low (n=42) or high (n=42) dose of vesnarinone. Dietary intake of vesnarinone minimized the BLM toxicity as reflected by significant decreases in numbers of inflammatory cells, KC, and soluble TNF receptors in the bronchoalveolar lavage fluid. A quantitative evaluation of histology demonstrated significantly mild lung parenchymal lesions in BLM-treated mice fed with diet containing high dose of vesnarinone than in the control diet group. Consistent with the histopathology, hydroxyproline levels in lung tissue from BLM-treated mice fed with diet containing vesnarinone were significantly lower than that from mice fed with control diet. We concluded that vesnarinone inhibits BLM-induced pulmonary fibrosis, at least in part, by the inhibition of acute lung injuries in the early phase. Ivyspring International Publisher 2009-04-16 /pmc/articles/PMC2669598/ /pubmed/19381349 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Research Paper Inage, Minoru Nakamura, Hidenori Saito, Hiroshi Abe, Shuichi Hino, Toshihiko Takabatake, Noriaki Terashita, Kyoko Ogura, Manabu Kato, Shuichi Hosokawa, Tetsumi Sata, Makoto Tomoike, Hitonobu Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin |
title | Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin |
title_full | Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin |
title_fullStr | Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin |
title_full_unstemmed | Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin |
title_short | Vesnarinone Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin |
title_sort | vesnarinone represses the fibrotic changes in murine lung injury induced by bleomycin |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669598/ https://www.ncbi.nlm.nih.gov/pubmed/19381349 |
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